The fatigue stress-life (S-N) behavior of E319 cast aluminum alloy was studied by using both ultrasonic and conventional fatigue techniques in order to understand the potential effect of frequency on fatigue behavior of cast aluminum alloys. It was observed that, at the investigated temperature (20°C, 150°C, and 250°C), fatigue life in air at 20 kHz is 5 to 10 times longer than that at 75 Hz. The difference in fatigue life between 20 kHz and 75 Hz is attributable to an environmental effect on fatigue crack growth rate. The effect of frequency, environment, and temperature on S-N behavior of E319 cast aluminum alloy can be predicted by use of a general version of a modified environmental superposition model. Environmental effects need to be considered when ultrasonic fatigue is used for estimating fatigue lives of aluminum alloys that are under cyclic loading at lower frequencies in service. It is possible to extrapolate ultrasonic fatigue data to conventional fatigue behavior for an E319 cast aluminum alloy based on the environmental superposition model.