Modeling glucose isomerization in a packed bed reactor using a new approach to the Briggs-Haldane mechanism

Carrazco-Escalante, Marco; Hernández‐Calderón, Oscar M.; Iribe-Salazar, Rosalina; Vázquez-López, Yessica; Rios‐Iribe, Erika Y.; Alarid-García, C.; Caro‐Corrales, José

doi:10.24275/rmiq/cat2474

Cited by 3 publications

(3 citation statements)

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“…[45,53] Meanwhile, the inactivation mechanism of GI of Streptomyces murinus has been described as one-stage firstorder. [54] In this work, parameters g 1 and g 2 correspond to b-gal and GI fractional residual activity, respectively, due to enzyme thermal inactivation.…”

Section: Enzyme Thermal Inactivationmentioning

confidence: 99%

“…The latter is the case of

{\beta }

‐gal from Aspergillus oryzae , which has been described as a two‐stage series mechanism [45,53] . Meanwhile, the inactivation mechanism of GI of Streptomyces murinus has been described as one‐stage first‐order [54] . In this work, parameters

{\gamma _1 }

and

{\gamma _2 }

correspond to

{\beta }

‐gal and GI fractional residual activity, respectively, due to enzyme thermal inactivation.…”

Section: Model Developmentmentioning

confidence: 99%

See 1 more Smart Citation

One‐pot Heterogeneous Biocatalysis under Thermal Decay for Fructose Production from Lactose using Co‐Immobilized Enzymes: Modeling and Simulation

Silva,

Illanes,

Wilson

et al. 2024

ChemCatChem

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Multi‐enzyme reaction systems have become an interesting option to avoid transformation and purification steps in productive reactor‐based systems; when carried out in a single vessel, they are termed one‐pot systems. This novel work aims to model and simulate the behavior of a one‐pot heterogeneous catalysis system in a batch‐stirred bioreactor and in a continuous stirred bioreactor with co‐immobilized enzymes to determine the compromise operation temperature that maximizes the volumetric productivity, considering thermal decay of the biocatalyst. The production of fructose from lactose is considered a case study, using coimmobilized β‐galactosidase (β‐gal) and glucose‐isomerase (GI) in a spherical particle. A diffusion and reaction mathematical model was used to calculate the effectiveness factor for every reaction species considering the thermal decay of both enzymes. Simulations in both batch and continuous operation were done at temperatures ranging from 40 to 60°C, for initial enzyme activity load ratios ranging from 0.1 to 0.9 IUGI IU−β‐1gal. Resulting effectiveness factors were close to one, indicating no significant limitations on reaction rates due to internal diffusional constraints. In both cases, temperature exerted a more substantial effect than the initial enzyme activity load ratio, showing different scenarios of high volumetric productivity (batch) or amount of produced fructose (continuous).

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Section: Enzyme Thermal Inactivationmentioning

confidence: 99%

“…The latter is the case of

{\beta }

{\gamma _1 }

and

{\gamma _2 }

correspond to

{\beta }

‐gal and GI fractional residual activity, respectively, due to enzyme thermal inactivation.…”

Section: Model Developmentmentioning

confidence: 99%

One‐pot Heterogeneous Biocatalysis under Thermal Decay for Fructose Production from Lactose using Co‐Immobilized Enzymes: Modeling and Simulation

Silva,

Illanes,

Wilson

et al. 2024

ChemCatChem

View full text Add to dashboard Cite

show abstract

“…MRs are an option for the conversion of large molecular size substrates; in this case, the membrane retains not only the enzyme, but also the unreacted starting material (Pottratz et al, 2022). Several factors are involved in the reactor selection and operation mode, being productivity (amount of product per unit of reactor volume and unit of time) and product-to-biocatalyst ratio (amount of product per unit of biocatalyst) the most important from an applicative standpoint (Grubecki and Kazimierska-Drobny, 2019;Carrazco-Escalante et al, 2021;Lindeque and Woodley, 2022).…”

Section: Continuous Reactors In a Nutshell: Selected Layouts And Appl...mentioning

confidence: 99%

What’s new in flow biocatalysis? A snapshot of 2020–2022

et al. 2023

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Flow biocatalysis is a key enabling technology that is increasingly being applied to a wide array of reactions with the aim of achieving process intensification, better control of biotransformations, and minimization of waste stream. In this mini-review, selected applications of flow biocatalysis to the preparation of food ingredients, APIs and fat- and oil-derived commodity chemicals, covering the period 2020-2022, are described.

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Modeling glucose isomerization in a packed- bed reactor: A complete theoretical and numerical approach

Rajaram¹,

Mariappan²,

Visuvasam³

et al. 2023

International Journal of Electrochemical Science

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Modeling glucose isomerization in a packed bed reactor using a new approach to the Briggs-Haldane mechanism

Cited by 3 publications

References 0 publications

One‐pot Heterogeneous Biocatalysis under Thermal Decay for Fructose Production from Lactose using Co‐Immobilized Enzymes: Modeling and Simulation

One‐pot Heterogeneous Biocatalysis under Thermal Decay for Fructose Production from Lactose using Co‐Immobilized Enzymes: Modeling and Simulation

What’s new in flow biocatalysis? A snapshot of 2020–2022

Modeling glucose isomerization in a packed- bed reactor: A complete theoretical and numerical approach

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