Modeling Electrospinning of Nanofibers

Kowalewski, T. A.; Barral, S.; Kowalczyk, Tomasz

doi:10.1007/978-1-4020-9557-3_29

Cited by 31 publications

(28 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This search of the most stable process has been performed following the guideline of previous works conducted with some other polymer trials. [55,56] The selected parameters have been maintained for the spinning of the three materials: PLLA0, PLLA1, and PLLA5. There are some key parameters that could affect the process in a greater extent than others.…”

Section: Electrospinning Process Setupmentioning

confidence: 99%

Electrospinning of poly(lactic acid)/polyhedral oligomeric silsesquioxane nanocomposites and their potential in chondrogenic tissue regeneration

Gómez-Sánchez

Kowalczyk

Eguino

et al. 2014

Journal of Biomaterials Science, Polymer Edition

Self Cite

View full text Add to dashboard Cite

The study was conducted to evaluate the cytocompatibility and hydrolytic degradability of the new poly(lactic acid)/polyethylene glycol-polyhedral oligomeric silsesquioxane (peg-POSS/PLLA) nanocomposite as potential material for cartilage regeneration. PLLA scaffolds containing 0 to 5% of peg-POSS were fabricated by electrospinning. Human mesenchymal stem cells (hMSC's) were cultured in vitro to evaluate the cytocompatibility of the new nanocomposite material. Hydrolytic degradation studies were also carried out to analyze the mass loss rate of the nanocomposites through time. The addition of the peg-POSS to the PLLA did not affect the processability of the nanocomposite by electrospinning. It was also observed that peg-POSS did not show any relevant change in fibers morphology, concluding that it was well dispersed. However, addition of peg-POSS caused noticeable decrease in mean fiber diameter, which made the specific surface area of the scaffold to rise. hMSC's were able to attach, to proliferate, and to differentiate into chondrocytes in a similar way onto the different types of electrospun peg-POSS/PLLA and pure PLLA scaffolds, showing that the peg-POSS as nano-additive does not exhibit any cytotoxicity. The hydrolytic degradation rate of the material was lower when peg-POSS was added, showing a higher durability of the nanocomposites through time. Results demonstrate that the addition of peg-POSS to the PLLA scaffolds does not affect its cytocompatibility to obtain hyaline cartilage from hMSC's.

show abstract

Section: Electrospinning Process Setupmentioning

confidence: 99%

Electrospinning of poly(lactic acid)/polyhedral oligomeric silsesquioxane nanocomposites and their potential in chondrogenic tissue regeneration

Gómez-Sánchez

Kowalczyk

Eguino

et al. 2014

Journal of Biomaterials Science, Polymer Edition

Self Cite

View full text Add to dashboard Cite

show abstract

“…For example, Kowalewski et al [32] demonstrated for the case of glycerol a stabilization purely by the viscous forces of the Newtonian liquid. However, this viscosity-controlled stabilization is possible only to stretch ratios ε on the order of O (10).…”

Section: Shear Rheologymentioning

confidence: 99%

The role of interfacial viscoelasticity in the stabilization of an electrospun jet

Regev

Vandebril

Zussman

et al. 2010

Polymer

View full text Add to dashboard Cite

Stabilization of the jet is necessary for the successful fabrication of continuous fibers from solutions via electrospinning. Although intensively studied over the past decade, the mechanisms underlying jet stabilization are still not precisely understood. The traditional explanation for jet stabilization emphasizes the role of the elastic response of the polymer coil in creating a sufficiently high extensional viscosity, which prevents the breakup of the filament under extension. However, comprehensive rheological studies of bovine serum albumin (BSA) solutions that can be electrospun into continuous fibers show an absence of any significant bulk elasticity in shear and extension that would account for the stabilization of the jet. In order to explain this discrepancy, it is proposed that a complex jet structure, composed of a liquid core surrounded by a viscoelastic interface, is formed during the spinning process, where the surface viscoelasticity is responsible for the jet stabilization. These rheological properties of the surface are experimentally verified using novel interfacial rheometry. It is also shown that the surface viscoelasticity is further enhanced by varying the protein conformation (unfolding), as well as its concentration in solution.2

show abstract

“…An efficient handling of long-range interactions can theoretically achieve O (n log n) operation count, or even O (n) for the fast multipole method (FMM). The proposed here treecode algorithm [7] considers particle-cluster interactions and achieves O (n log n) complexity. Generally it is a time-dependent three-dimensional generalization of known slender models [2,4,5,8], and solves the mass and momentum conservation equation for the Maxwell viscoelastic fluid.…”

Section: Copyright Line Will Be Provided By the Publishermentioning

confidence: 99%

“…A small random perturbation to the position of each element introduced at the inlet is imposed, so as to initiate the bending instability. The magnitude of this perturbation has no notable influence on the simulation results, provided that it is small enough [7].…”

Section: Copyright Line Will Be Provided By the Publishermentioning

confidence: 99%

Modelling electrospinning of nanofibres

Kowalewski

Barral

2009

Proc Appl Math and Mech

View full text Add to dashboard Cite

Electrospinning is based on so-called bending instability which results in an erratic spiralling motion of the liquid jet as it proceeds towards a collecting electrode, where it is eventually deposited as a mat of micro/nanosized fibres. Most electrospinning models formulated within the slender approximation rely, however, on an inconsistent description of electrostatic interactions which renders them grossly inappropriate whenever the discretization is either too coarse or too fine. The present work aims at proposing a discrete slender model which is numerically consistent (allowing use of arbitrary fine meshes) and remains accurate even for coarse meshes. At the same time, efficient numerical techniques based on hierarchical charge clustering are introduced that drastically decrease computational times. Finally, a versatile boundary value method is implemented to enforce fixed-potential boundary conditions, allowing realistic electrode configurations to be investigated.Copyright line will be provided by the publisher Electrospinning is a simple and relatively inexpensive mean of producing continuous fibres with diameters ranging from micrometers down to a few nanometres. Nonwovens of electrospun fibres are obtained from a jet of polymer solution stretched by an electric field. Although most polymeric solutions or melts may be used for electrospinning, the achievement of stable operation is usually the result of a tedious trial-and-error parametrical optimization procedure. On the other hand the physical and mathematical description of the electrospinning process remain in a premature state. The existing discrete models are based on point charges connected by dumbbell elements [1][2][3][4][5]. One serious concern relates to the evaluation of short-range interactions, which in the case of standard discrete integration methods require very dense grids due to the large contribution of short-range electrostatic interactions within distances of the order of the fibre radius [1,6]. As the fibre radius is about 10 3 − 10 5 times smaller than the macroscopic scales of interest, it appears most desirable to devise a discrete model that exploits the slenderness of the fibre to evaluate short-range interactions in an efficient manner. Likewise, the computation of long-range electrostatic interactions can easily become intractable due to the O n 2 operation count for a pairwise evaluation of interactions between n elements. In addition current numerical models are based on the assumption of a static external electric field, whereas in reality the external field is modulated by the net space charge of the fibre so as to keep constant the potential over the electrodes. An efficient handling of long-range interactions can theoretically achieve O (n log n) operation count, or even O (n) for the fast multipole method (FMM). The proposed here treecode algorithm [7] considers particle-cluster interactions and achieves O (n log n) complexity. Generally it is a time-dependent three-dimensional generalization of known slender models...

show abstract

Modeling Electrospinning of Nanofibers

Cited by 31 publications

References 22 publications

Electrospinning of poly(lactic acid)/polyhedral oligomeric silsesquioxane nanocomposites and their potential in chondrogenic tissue regeneration

Electrospinning of poly(lactic acid)/polyhedral oligomeric silsesquioxane nanocomposites and their potential in chondrogenic tissue regeneration

The role of interfacial viscoelasticity in the stabilization of an electrospun jet

Modelling electrospinning of nanofibres

Contact Info

Product

Resources

About