Modeling Effects of Scar on Patterns of Dorsal Column Stimulation

High-Resolution Multi-Scale Computational Model for Non-Invasive Cervical Vagus Nerve Stimulation

“…In trying to encompass the scale needed for non‐invasive stimulation, some limitations did arise. Previous VNS models have considered finer physiological detail including distribution of fibers in fascicles, varying fiber dynamics, blockage threshold, and the presence of local polarity peaks (virtual anodes and cathodes). These studies can be leveraged in future work to develop more physiologically detailed models.…”

“…Computational current flow and neuron activation models underpin brain stimulation design. Prior modeling efforts have focused on invasive VNS or peripheral nerve stimulation in general, but have not included the macroscopic and mesoscopic details that may be relevant to nVNS . Invasive VNS protocols typically have electrode cuffs positioned directly on the nerve itself, whereas nVNS electrodes are in contact with skin.…”

Spinal Cord Stimulator Explantation: Motives for Removal of Surgically Placed Paddle Systems

“…The other 2 patients had their stimulators in for over 1 year, and both presented with adequate pain control but progressive subjective weakness, which was verified clinically. One mechanism for which this occurred is postulated to be epidural scar formation through dorsal column stimulation; however, other causes for the myelopathy were not determined at the time of surgery, so records of the workup were not available.…”

High-Frequency Stimulation of Dorsal Column Axons: Potential Underlying Mechanism of Paresthesia-Free Neuropathic Pain Relief

“… Slice plot of electric potential under the cathode in the FEM. Our model, including its dimensions and tissue conductivities, closely follows that of Wesselink et al and details are in Arle et al . Shown is a cathode sitting on the dura mater , inside of which is the cerebrospinal fluid (CSF), dorsal roots, white matter and gray matter.…”