Modeling Early-Onset Postischemic Seizures in Adult and Aging Mice

Stroke-Onset Seizures During Midbrain Infarction in a Patient With Top of the Basilar Syndrome

“…44 We also pointed out that Zhang et al recorded epileptic discharges from the brainstem, but not from the hippocampi or neocortex, during MCAO-induced convulsive seizures. 37 The stereotyped nature of the 4 clonic episodes in our patient and their rarity (only 1 episode of all-limb jerking and 3 episodes of leg jerking occurred over a 3-week period) point toward clonic seizures. However, the absence of a clear-cut change in the EEG during all-limb jerking and the absence of an ictal EEG correlate during leg jerking raise the possibility that the convulsive movements were not seizures.…”

“… 36 Zhang et al noted a striking similarity between convulsive seizures induced by the MCAO model and convulsive seizures induced by the hypoxia-ischemia model. 37 Interestingly, epileptiform discharges were recorded from brainstem areas but not from the hippocampi or neocortex. MCAO also produced nonconvulsive seizures with the ictal EEG showing epileptiform spikes in the hippocampi and neocortex.…”

“…MCAO also produced nonconvulsive seizures with the ictal EEG showing epileptiform spikes in the hippocampi and neocortex. 37 While all animals with nonconvulsive seizures subsequently developed convulsive seizures, not all animals with convulsive seizures experienced a preceding nonconvulsive seizure. Animals that eventually developed convulsive seizures had worse outcomes than those with nonconvulsive seizures alone.…”

“…32 Early-onset seizures have been studied in rodents using models of acute ischemic stroke, such as unilateral middle cerebral artery occlusion (MCAO) or photothrombotic ischemia. [33][34][35][36][37] Using the MCAO technique, Wu et al showed that deeper subcortical structures are crucial for generating convulsive seizures. 36 Zhang et al noted a striking similarity between convulsive seizures induced by the MCAO model and convulsive seizures induced by the hypoxia-ischemia model.…”