Modeling Drugs-PLGA Nanoparticles Interactions Using Gaussian Processes: Pharmaceutics Informatics Approach

Hathout, Rania M.; Mahmoud, Orchid A; Ali, Dalia S.; Mamdouh, Marina; Metwally, Abdelkader A.

doi:10.1007/s10876-021-02126-0

Cited by 9 publications

(6 citation statements)

References 29 publications

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“… Forest plot of optimized meta-analysis for the studies: [ 1 , 2 , 3 , 5 , 6 , 7 , 8 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 19 ], according to OpenMetaAnalyst software. …”

Section: Figurementioning

confidence: 99%

“… Forest plot of investigated subgroups: (c) naturally originated material of nanoparticulate systems versus (d) synthetically originated material of nanoparticulate system for the studies: [ 1 , 2 , 3 , 5 , 6 , 7 , 8 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 19 ], (OpenMetaAnalyst). …”

Section: Figurementioning

confidence: 99%

“…The lipid vehicles’ strongest advantage lies in the high affinity to the neurons and blood–brain barrier (BBB). On the other hand, the polymeric counterparts are more stable, robust, and easily modulated and conjugated [ 6 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…To this end, systematic reviewing and meta-analysis were used in the current study as pharmaceutics informatics tools [ 15 , 25 ] in order to track the influence of delivering drugs utilizing nanoparticulate systems on the area under the curve (AUC) as an in vivo pharmacokinetic parameter and important indicator of the superior bioavailability of these advanced carriers to the conventional formulations. Furthermore, an additional covariate factor was assessed, specifically the type of the used nanoparticulate system, e.g., lipids such as liposomes, solid lipid nanoparticles, and lipid nanocapsules versus the polymeric such as chitosan, PLGA, Pullulan, and zein.…”

Section: Introductionmentioning

confidence: 99%

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Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers

Hathout

El-Marakby

2022

Bioengineering

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Objectives: The intranasal route represents a high promising route of administration aiming for brain delivery. Yet, it represents one of the most difficult and complicated routes. Accordingly, scientists are in a continuous search for novel drug delivery vehicles such as the lipid and polymeric nanoparticles that are apt to enhance the bioavailability of the administered drugs to reach the brain. In this study, a certain number of publications were selected from different databases and literature. Meta-analysis studies using two different algorithms (DerSimonian–Laird and inverse variance) followed aiming to explore the published studies and confirm by evidence the superiority of nanocarriers in enhancing the brain bioavailability of various drugs. Furthermore, the quantitative comparison of lipid versus polymeric nanosystems was performed. Methods: The area under the curve (AUC) as an important pharmacokinetic parameter extracted from in vivo animal studies was designated as the “effect” in the performed meta-analysis after normalization. Forest plots were generated. Key findings and Conclusions: The meta-analysis confirmed the augmentation of the AUC after the comparison with traditional preparations such as solutions and suspensions. Most importantly, lipid nanoparticles were proven to be significantly superior to the polymeric counterparts.

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“… Forest plot of optimized meta-analysis for the studies: [ 1 , 2 , 3 , 5 , 6 , 7 , 8 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 19 ], according to OpenMetaAnalyst software. …”

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers

Hathout

El-Marakby

2022

Bioengineering

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“…From the pharmaceutical point of view, polymeric nanoparticles are of special interest as they are more stable than other lipidic nanocarriers, such as liposomes, and impart more protective effects to their internal cargo [ 7 , 8 , 9 ]. Furthermore, they are distinguished by their facile modulation regarding their size, hydrophobicity, and surface grafting and conjugation [ 10 , 11 , 12 , 13 ]. Accordingly, the same informatics tools of systematic reviewing and meta-analysis are utilized in this study to answer this question.…”

Section: Introductionmentioning

confidence: 99%

Do Polymeric Nanoparticles Really Enhance the Bioavailability of Oral Drugs? A Quantitative Answer Using Meta-Analysis

Hathout

2022

Gels

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The oral route remains one of the most popular and important routes of administration for drugs—one that warrants the development of advanced drug delivery systems, such as polymeric nanoparticles capable of enhancing the absorption and bioavailability of the used drugs. In this work, a systematic review of published works on several databases, followed by a meta-analysis, were utilized in order to navigate the published studies and access literature-based evidence about the capability of polymeric nanoparticulate systems to augment the absorption and bioavailability of orally administered drugs. The pharmacokinetic parameter of the area under the curve (AUC) was utilized as the “effect” of this meta-analytical study. The meta-analysis demonstrated a significant increase in AUC compared to conventional formulations. Furthermore, comparing the synthetic polymeric nanoparticles, versus their naturally-based administered counterparts, as subgroups of the meta-analysis, revealed no significant differences.

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Polyester-based long acting injectables: Advancements in molecular dynamics simulation and technological insights

Kotla

Pandey

et al. 2023

Drug Discovery Today

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Modeling Drugs-PLGA Nanoparticles Interactions Using Gaussian Processes: Pharmaceutics Informatics Approach

Cited by 9 publications

References 29 publications

Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers

Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers

Do Polymeric Nanoparticles Really Enhance the Bioavailability of Oral Drugs? A Quantitative Answer Using Meta-Analysis

Polyester-based long acting injectables: Advancements in molecular dynamics simulation and technological insights

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