Modeling drug release through stimuli responsive polymer hydrogels

Pareek, Aditya; Maheshwari, Shantanu; Cherlo, Sivakumar; Thavva, Rama Subba Reddy; Runkana, Venkataramana

doi:10.1016/j.ijpharm.2017.09.001

Cited by 17 publications

(2 citation statements)

References 58 publications

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“…Techniques such as rheology, scanning electron microscopy (SEM), and atomic force microscopy (AFM) facilitate the understanding of mechanical behavior, morphology, and interfacial interactions of the hydrogels at different scales (Rao et al, 2017). Computational modeling, on the other hand, allows for the prediction and simulation of drug release kinetics, swelling behavior, and mechanical properties, aiding in efficient design and optimization (Pareek et al, 2017). Looking ahead, future directions in the field of Tragacanth gum-based hydrogels encompass various aspects.…”

Section: Future Perspectives and Challengesmentioning

confidence: 99%

Tragacanth gum-based hydrogels for drug delivery and tissue engineering applications

Abdi,

Jain,

Patil

et al. 2024

Front. Mater.

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Natural polymers have many uses, and Tragacanth gum is just one of them. Many people are interested in natural gums because of their many attractive characteristics, such as being ‘green’ bio-based renewable materials, being easily accessible, inexpensive, and structurally diverse. One class of naturally occurring polysaccharides is called gum because of its tendency to create a gel or a thick solution. Among the many plant-based raw materials, these polysaccharide gums are abundant. Hydrogels, which are three-dimensional polymeric webs that can imitate live tissues, have demonstrated remarkable potential as adjustable biomaterials in numerous regenerative techniques due to their high water or biological exudate absorption capacities. Natural polysaccharides, often known as gums, are present in many different types of trees and possess many desirable properties, such as being renewable, biocompatible, biodegradable, non-toxic, and amenable to chemical modification. Many people are curious about certain parts of the food, water, energy, biotech, environmental, and healthcare sectors as of now. Gum, a type of very important and unique food ingredient, has many vital uses in the food business. Cosmetics, coating, photosensitive resin, fertilizer, casting, pharmaceuticals, and tobacco are just a few of the non-food businesses that make use of their strong water-affinity and structural plasticity. There are a lot of benefits to hydrogels made from natural gums as opposed to those made from synthetic sources. Synthesis hydrogel polymers have been the center of interest among these non-food applications because of their extensive use in the pharmaceutical and medical fields. The Tragacanth gum hydrogels used for medication delivery and tissue engineering have been the focus of this study. We also paid close attention to drug delivery, physical-chemical properties, and the extraction of Tragacanth gum. Our research has a wide range of biomedical applications, including tissue engineering for bone, skin, fixation of bone, periodontal, and cartilage. Possible futures based on hydrogels made of Tragacanth gum were likewise our primary focus.

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Section: Future Perspectives and Challengesmentioning

confidence: 99%

Tragacanth gum-based hydrogels for drug delivery and tissue engineering applications

Abdi,

Jain,

Patil

et al. 2024

Front. Mater.

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“…Deacetylated gellan gum can immediately form a threedimensional gel network structure when it encounters monovalent or divalent cations (K þ , Na þ , Ca 2þ ), thus can also be used in situ hydrogel anti-tumor drug delivery system (Rupenthal et al, 2011;Janga et al, 2018;Yang et al, 2018). Due to the good biocompatibility, hydrophilicity and low toxicity related to commonly biogenic nature of drug carrier materials, this type of hydrogel deserves indepth studies and exploitment (Pareek et al, 2017;Shang et al, 2018).…”

Section: Ionic Strength Sensitive In Situ Hydrogelmentioning

confidence: 99%

Research progress in the application of in situ hydrogel system in tumor treatment

Wei

Yin

et al. 2020

Drug Delivery

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The in situ hydrogel drug delivery system is a hot research topic in recent years. Combining both properties of hydrogel and solution, in situ hydrogels can provide many advantages for drug delivery application, including easy application, high local drug concentration, prolonged drug retention time, reduced drug dose in vivo, good biocompatibility and improved patient compliance, thus has potential in tumor treatment. In this paper, the related literature reports in recent years were reviewed to summarize and discuss the research progress and development prospects in the application of in situ hydrogels in tumor treatment. ARTICLE HISTORY

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Investigation of a Drug Release Moving Boundary Problem in a Swelling Polymeric Device

Garshasbi

Bagomghaleh

2022

Int. J. Appl. Comput. Math

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Modeling drug release through stimuli responsive polymer hydrogels

Cited by 17 publications

References 58 publications

Tragacanth gum-based hydrogels for drug delivery and tissue engineering applications

Tragacanth gum-based hydrogels for drug delivery and tissue engineering applications

Research progress in the application of in situ hydrogel system in tumor treatment

Investigation of a Drug Release Moving Boundary Problem in a Swelling Polymeric Device

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