“…TNFα and ROS significantly increase preceding cardiac damage and dysfunction following trauma, sepsis, and myocardial ischemia [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. Local cardiac inflammatory response and oxidative stress have been demonstrated as the primary driving force for cardiomyocyte impairment and functional damage following these injuries [ 8 , 19 , 21 , 22 , 23 , 24 , 25 , 26 ]. On the other hand, sex dimorphism impacts consequences after trauma, sepsis, or myocardial ischemia [ 27 , 28 , 29 , 30 , 31 , 32 ].…”