Modeling Breath-Enhanced Jet Nebulizers to Estimate Pulmonary Drug Deposition

Wee, Wallace; Leung, Kitty; Coates, Allan L.

doi:10.1089/jamp.2012.0984

Cited by 8 publications

(2 citation statements)

References 29 publications

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“…Several of the antibiotics were administered in their raw form or as a novel compound in order to enhance the absorption [2]. The different methods of the aerosol administration can be found on Table 1 [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47]. The drugs have been administered for pulmonary infections in several conditions such as; pneumonia, cystic fibrosis and bronchiectasis.…”

Section: Antibioticsmentioning

confidence: 99%

Drug development of Lung Diseases by way of Drug Repurposing; What a Pulmonary Physician can do in the Laboratory

Tsiouda¹,

Hohenforst-Schmidt²,

Sardeli³

et al. 2018

J. Biomed

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Lung diseases are very common among several patients such as; asthma, chronic obstructive pulmonary disease, lung cancer, cystic fibrosis and pulmonary fibrosis. In many of these diseases we already have inhalation therapies, however; for others we have only systematic administration. There are also diseases of the lung that cause pulmonary hypertension and architectural damage to the lung such as; emphysema and bronchiectasis. Several of the drugs currently administered intravenously are being investigated whether they could be transformed and delivered as aerosol therapy. We will present the methodology that can be used and has been used for several drugs.

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Section: Antibioticsmentioning

confidence: 99%

Drug development of Lung Diseases by way of Drug Repurposing; What a Pulmonary Physician can do in the Laboratory

Tsiouda¹,

Hohenforst-Schmidt²,

Sardeli³

et al. 2018

J. Biomed

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“…Local deposition was increased two-fold with addition of 100 Hz acoustic airflow, but did not overcome the local “anatomy” deposition factor. In the study by Wee et al,117 an aerosol was investigated using a method incorporating mathematical model derivation, in vitro testing, and in vivo testing.…”

Section: Production Systems and Evaluation Modelsmentioning

confidence: 99%

Clinical experimentation with aerosol antibiotics: current and future methods of administration

Zarogoulidis¹,

Kioumis²,

Porpodis³

et al. 2013

DDDT

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Currently almost all antibiotics are administered by the intravenous route. Since several systems and situations require more efficient methods of administration, investigation and experimentation in drug design has produced local treatment modalities. Administration of antibiotics in aerosol form is one of the treatment methods of increasing interest. As the field of drug nanotechnology grows, new molecules have been produced and combined with aerosol production systems. In the current review, we discuss the efficiency of aerosol antibiotic studies along with aerosol production systems. The different parts of the aerosol antibiotic methodology are presented. Additionally, information regarding the drug molecules used is presented and future applications of this method are discussed.

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Introduction to the respiratory tract

Finlay¹

2019

The Mechanics of Inhaled Pharmaceutical Aerosols

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Modeling Breath-Enhanced Jet Nebulizers to Estimate Pulmonary Drug Deposition

Cited by 8 publications

References 29 publications

Drug development of Lung Diseases by way of Drug Repurposing; What a Pulmonary Physician can do in the Laboratory

Drug development of Lung Diseases by way of Drug Repurposing; What a Pulmonary Physician can do in the Laboratory

Clinical experimentation with aerosol antibiotics: current and future methods of administration

Introduction to the respiratory tract

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