“…These crystallization systems are usually modeled by utilizing population balance equations (PBEs), as a well-designed mathematical framework for describing the growth, nucleation, breakage, and agglomeration of crystals . The PBE was extended to crystallization by including expressions for nucleation and growth. , The PBEs have been applied for estimating and modeling various crystallization systems. ,,− However, PBE containing breakage and agglomeration terms, which are commonly expressed as integral functions, are so complex that analytic solution of the PBE could not be obtained . Although solutions of the PBE could be obtained by several numerical methods, such as the method of moments, , the method of characteristics, discretized population balances, − and weighted residuals, the computation time for model solving is significantly long and it is too difficult to estimate the parameters required for expressing the breakage and agglomeration phenomena.…”