Modeling and Simulation of Respiratory System for Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19

Abstract

The respiratory system is one of the complicated systems in the human body. In this paper, the mathematical model for the respiratory system was proposed based on the electro-acoustic bio-impedance analysis with huge number of equations. Further, the behavior of each generation from 24 generations of the respiratory system can be analyzed separately. Furthermore, the pressure with ventilated frequency from 1-1200 min -1 at any generation can be predicted and calculated. The proposed mathematical model was validated by comparison the results with the published results. The simulated results for ARDS disease are presented. Also, the comparison between normal case (healthy) and ARDS diseased case is presented. The proposed mathematical model with huge number of equations is implemented by Matlab program package. This proposed mathematical model can be used as a reversed problem solution to detect and diagnose the medical situation of the respiratory system for patients especially patients associated with COVID-19.

Short Review for Design and Implementation of a New Low-Cost Prototype Portable Smart Ventilator

“…Eldosoky et al ( 2021) presented a ventilator depends on its work on the Matlab program, where a large set of mathematical equations has been proposed to be implemented by the MATLAB program, and its results were accurate because all its equations were calculated directly without any assumptions. As the medical condition of the patient's respiratory system was self-diagnosed and detected by the proposed mathematical model [4].…”

“…Respiratory distress syndrome is one of the symptoms of coronavirus infection, as it impairs the lung's ability to exchange gases from oxygen and carbon dioxide, which causes hypoxia in blood, shortness of breath, bluish skin and thus death. Therefore, there was an urgent need to develop a mechanical breathing device in order to support the condition of patients in the intensive care unit, as well as to overcome this pandemic [4]. Where different designs and sizes of the ventilator were produced in order to compensate for the shortage of ventilators all over the world, especially during the outbreak of the virus.…”

Wireless sensor and wireless body area network assisted biosensor network for effective monitoring and prevention of non-ventilator hospital-acquired pneumonia

“…Carbon dioxide, a byproduct of cellular metabolism, can significantly affect the lungs, which may be of therapeutic importance in very unwell patients, especially those with acute respiratory distress syndrome (ARDS) (Mehrabadi et al, 2021;Awad et al, 2022). Numerous reports have shown that CO 2 may harm the lungs regardless of pH (Kacmarek et al, 2018;Pirapuraj et al, 2021).…”