Modeling and simulation of novel antenna for the treatment of hepatocellular carcinoma using finite element method

Maini, Surita; Marwaha, Anupma

doi:10.3109/15368378.2012.721849

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…In addition to experimental methods, computer modeling is a powerful tool for improving the performance of MWA devices and procedures. Moreover, numerical models of the antenna-tissue system are essential for investigating thermal spread through the tissue [ 36 , 37 , 38 , 39 ]. Several numerical studies have predicted the temperature profile and accompanying tissue damage caused by the MWA applicator [ 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

Computational Modeling of Microwave Tumor Ablation

Radmilović-Radjenović

Bošković

Radjenović

2022

Bioengineering

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Microwave ablation is recognized as a minimally invasive, fast-recovery treatment for destroying cancer cells using the heat generated by microwave energy. Despite the unquestionable benefits of microwave ablation, the interaction of the microwave applicator with the tissue may result in localized heating and damage to the surrounding tissue. The majority of the tissue damage can be removed by clarifying the conditions for their development. In addition to experimental methods, computer modeling has proven to be an effective tool for optimizing the performance of microwave ablation. Furthermore, because the thermal spread in biological tissue is difficult to measure, developing a predictive model from procedural planning to execution may have a substantial influence on patient care. The comprehension of heat transport in biological tissues plays a significant role in gaining insight into the mechanisms underlying microwave ablation. Numerical methods that enable ablation size control are required to guarantee tumor destruction and minimize damage to healthy tissues. Various values of input power and ablation time correspond to different tumor shapes ensuring the preservation of healthy tissues. The optimal conditions can be estimated by performing full three-dimensional simulations. This topical review recapitulates numerous computational studies on microwave tumor ablation. Novel areas emerging in treatment planning that exploit the advantages of numerical methods are also discussed. As an illustration, the results of the three-dimensional simulations of real liver tumors in the 3D-IRCADb-01 database are presented and analyzed. The simulation results confirm that numerical methods are very useful tools for modeling microwave tumor ablation with minimal invasiveness and collateral damage.

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Section: Introductionmentioning

confidence: 99%

Computational Modeling of Microwave Tumor Ablation

Radmilović-Radjenović

Bošković

Radjenović

2022

Bioengineering

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“…In further developments and improvements of the design and optimization of microwave ablation devices, a numerical model of the antenna-tissue system play a central role in providing vital information on the thermal behavior of the tissue [ 55 , 56 , 57 , 58 , 59 ]. The performance of the antenna has been estimated considering the specific absorption rate, antenna impedance, and geometry of the obtained thermal lesion [ 60 , 61 , 62 , 63 , 64 ]. Several numerical works are devoted to the prediction of the temperature profile in the tissue and resultant tissue damage created by ablation devices [ 65 , 66 ].…”

Section: Introductionmentioning

confidence: 99%

On Efficacy of Microwave Ablation in the Thermal Treatment of an Early-Stage Hepatocellular Carcinoma

Radjenović

Sabo

Šoltés

et al. 2021

Cancers

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Microwave ablation at 2.45 GHz is gaining popularity as an alternative therapy to hepatic resection with a higher overall survival rate than external beam radiation therapy and proton beam therapy. It also offers better long-term recurrence-free overall survival when compared with radiofrequency ablation. To improve the design and optimization of microwave ablation procedures, numerical models can provide crucial information. A three-dimensional model of the antenna and targeted tissue without homogeneity assumptions are the most realistic representation of the physical problem. Due to complexity and computational resources consumption, most of the existing numerical studies are based on using two-dimensional axisymmetric models to emulate actual three-dimensional cancers and surrounding tissue, which is often far from reality. The main goal of this study is to develop a fully three-dimensional model of a multislot microwave antenna immersed into liver tissue affected by early-stage hepatocellular carcinoma. The geometry of the tumor is taken from the 3D-IRCADb-01 liver tumors database. Simulations were performed involving the temperature dependence of the blood perfusion, dielectric and thermal properties of both healthy and tumoral liver tissues. The water content changes during the ablation process are also included. The optimal values of the input power and the ablation time are determined to ensure complete treatment of the tumor with minimal damage to the healthy tissue. It was found that a multislot antenna is designed to create predictable, large, spherical zones of the ablation that are not influenced by varying tissue environments. The obtained results may be useful for determining optimal conditions necessary for microwave ablation to be as effective as possible for treating early-stage hepatocellular carcinoma, with minimized invasiveness and collateral damages.

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