Modeling and Optimization of Microneedle Systems

Sandrakov, G. V.; Lyashko, S. I.; Bondar, O. S.; Lyashko, N. I.

doi:10.1615/jautomatinfscien.v51.i6.10

Cited by 18 publications

(10 citation statements)

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“…The geometry of the MN also needs to be considered [ 82 ]. However, as Sandrakov et al [ 131 ] proved that conical MNs are the most optimal, it is logical to start with conical geometry as a standard when modeling. The length of the MNs, both tip and base diameter of the MNs, center-to-center spacing between two MNs, numbers of MNs in the array, and the distribution of the MNs in an array (square, diamond, triangle, rectangle, or exceptional design), etc.…”

Section: Modeling and Optimization For Designing Polymeric Mnsmentioning

confidence: 99%

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric MNs) for the translation of MNs from laboratory to clinical practice. The review reveals that polymers are most appropriately used for dissolvable and swellable MNs due to their wide range of tunable properties and that natural polymers are an ideal material choice as they structurally mimic native cellular environments. It has also been concluded that natural and synthetic polymer combinations are useful as polymers usually lack mechanical strength, stability, or other desired properties for the fabrication and insertion of MNs. This review evaluates fabrication methods and materials choice, disease and health conditions, clinical challenges, and the future of MNs in public healthcare services, focusing on literature from the last decade.

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Section: Modeling and Optimization For Designing Polymeric Mnsmentioning

confidence: 99%

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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“…Тут u -концентрацiя лiкiв у тканинi, h -керування системою. На розв'язках задачi ( 1), ( 2) задано функцiонал якостi J(h) = Φ (u(h)) , який необхiдно мiнiмiзувати в областi допустимих керувань U. Права частина f рiвняння (1) може бути узагальненою функцiєю деякого скiнченного порядку (iмпульсне, точкове керування тощо) [15,[17][18][19][20].…”

Section: математична модельunclassified

“…2. Теорема iснування Спряжений до оператора L оператор L * визначається наступною системою [20,21]. 2), що вiдповiдають правим частинам f k у просторi L 2 (Q).…”

Section: математична модельunclassified

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Optimization of the Process of Drug Transport in the Artery

Bondar

2019

JNAM

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“…The homogenization theory for general variational inequalities were considered and developed for the corresponding problems in [7,8,9]. Specific asymptotic approximations for the problems of elastic interaction of a microneedle system with a surface were calculated in [10,11]. The UDK 517.9 case minimization problem considered herein more accurately models the microneedle systems made in the form of a patch.…”

mentioning

confidence: 99%

Approximations for the optimization problem for medical microneedle systems

Sandrakov

2021

Fìz.-mat. model. ìnf. tehnol.

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Microneedle systems are used for transdermal (hypodermic) medicine injections at the treatment of different diseases. The efficiency of using such systems depends significantly on the size and parameters of microneedles. The problem of determining such dependencies and optimal parameters is considered as the problem of optimizing the interaction of microneedle systems with an elastic surface. Minimization problems for integral functional, whose solutions are approximations for solutions to the interaction problem, are obtained by the homogenization theory methods. Such problems are formulated in the form of classical problems with obstacles .

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Modeling and Optimization of Microneedle Systems

Cited by 18 publications

References 0 publications

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Optimization of the Process of Drug Transport in the Artery

Approximations for the optimization problem for medical microneedle systems

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