Modeling and comparison of dissolution profiles

Costa, Paulo; Lobo, José Manuel Sousa

doi:10.1016/s0928-0987(01)00095-1

Cited by 4,402 publications

(2,947 citation statements)

References 50 publications

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“…Dissolution (process 4a) refers specifically to the release of individual ions or molecules that are soluble in water [4,[22][23][24]. The dissolution process can involve reaction of the surface molecules and ultimate release of the ionic form [21] or direct dissolution of the constituent materials, followed by a diffusional transport of the dissolved compounds [25].…”

Section: Nanoparticle Releasementioning

confidence: 99%

Potential scenarios for nanomaterial release and subsequent alteration in the environment

Nowack¹,

Ranville²,

Diamond³

et al. 2011

Enviro Toxic and Chemistry

522

353

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Abstract-The risks associated with exposure to engineered nanomaterials (ENM) will be determined in part by the processes that control their environmental fate and transformation. These processes act not only on ENM that might be released directly into the environment, but more importantly also on ENM in consumer products and those that have been released from the product. The environmental fate and transformation are likely to differ significantly for each of these cases. The ENM released from actual direct use or from nanomaterial-containing products are much more relevant for ecotoxicological studies and risk assessment than pristine ENM. Released ENM may have a greater or lesser environmental impact than the starting materials, depending on the transformation reactions and the material. Almost nothing is known about the environmental behavior and the effects of released and transformed ENM, although these are the materials that are actually present in the environment. Further research is needed to determine whether the release and transformation processes result in a similar or more diverse set of ENM and ultimately how this affects environmental behavior. This article addresses these questions, using four hypothetical case studies that cover a wide range of ENM, their direct use or product applications, and their likely fate in the environment. Furthermore, a more definitive classification scheme for ENM should be adopted that reflects their surface condition, which is a result of both industrial and environmental processes acting on the ENM. The authors conclude that it is not possible to assess the risks associated with the use of ENM by investigating only the pristine form of the ENM, without considering alterations and transformation processes. Environ. Toxicol. Chem. 2012;31:50-59. # 2011 SETAC

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Section: Nanoparticle Releasementioning

confidence: 99%

Potential scenarios for nanomaterial release and subsequent alteration in the environment

Nowack¹,

Ranville²,

Diamond³

et al. 2011

Enviro Toxic and Chemistry

522

353

View full text Add to dashboard Cite

show abstract

“…zero order, first order, Hixson-Crowell, Weibull, Higuchi, Baker-Lonsdale, Korsmeyer-Peppas and Hopfenberg models [50]) to identify underlying mechanisms involved in the release phenomena. In this work, the Korsmeyer Peppas (KP) model was selected due to its versatility and ability to provide insights regarding the limiting drug release mechanism.…”

Section: Drug Release Studymentioning

confidence: 99%

“…In this work, the Korsmeyer Peppas (KP) model was selected due to its versatility and ability to provide insights regarding the limiting drug release mechanism. The drug concentration released was correlated to Equation 3, where M t is the drug amount at time t, M ∞ is the maximum amount released from the material in the experimental conditions, k is a constant incorporating characteristics of the matrix and of the drug, and n is the diffusional exponent that is indicative of the limiting transport mechanism [50,51].…”

Section: Drug Release Studymentioning

confidence: 99%

Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement

Mestres

Kugiejko

Pastorino

et al. 2016

Materials Science and Engineering: C

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Calcium phosphate cements are synthetic bone graft substitutes able to set at physiological conditions. They can be applied by minimally invasive surgery and can also be used as drug delivery systems.Consequently, the drug release pattern from the cement paste (fresh cement) is of high clinical interest.However, previous studies have commonly evaluated the drug release using pre-set cements only.Therefore, the aim of this work was to determine if the time elapsed from cement preparation until immersion in the solution (3 min for fresh cements, and 1 h and 15 h for pre-set cements) had an influence on its physical properties, and correlating these to the drug release profile. Simvastatin was selected as a model drug, while brushite cement was used as drug carrier. This study quantified how the setting of a material reduces the accessibility of the release media to the material, thus preventing drug release. A shift in the drug release pattern was observed, from a burst-release for fresh cements to a sustained release for pre-set cements.

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“…The release profiles of Figs. 5 and 7 were fitted to different 354 kinetic models, in order to try to determine the mechanism driving 355 drug release (Costa and Sousa Lobo, 2001). Table 1 …”

mentioning

confidence: 99%

Tuning dual-drug release from composite scaffolds for bone regeneration

Paris

Román

Manzano

et al. 2015

International Journal of Pharmaceutics

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Keywords:Dual-drug delivery system Designed porous scaffold Ibuprofen Zoledronic acid Co-delivery release Tissue engineering A B S T R A C TThis work presents the tuning of drug-loaded scaffolds for bone regeneration as dual-drug delivery systems. Two therapeutic substances, zoledronic acid (anti-osteoporotic drug) and ibuprofen (antiinflammatory drug) were successfully incorporated in a controlled manner into three dimensional designed porous scaffolds of apatite/agarose composite. A high-performance liquid chromatography method was optimized to separate and simultaneously quantify the two drugs released from the dualdrug codelivery system. The multifunctional porous scaffolds fabricated show a very rapid delivery of anti-inflammatory (interesting to reduce inflammation after implantation), whereas the antiosteoporotic drug showed sustained release behaviour (important to promote bone regeneration). Since ibuprofen release was faster than desired, this drug was encapsulated in chitosan spheres which were then incorporated into the scaffolds, obtaining a release profile suitable for clinical application. The results obtained open the possibility to simultaneously incorporate two or more drugs to an osseous implant in a controlled way improving it for bone healing application.2015 Published by Elsevier B.V. 7

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Modeling and comparison of dissolution profiles

Cited by 4,402 publications

References 50 publications

Potential scenarios for nanomaterial release and subsequent alteration in the environment

Potential scenarios for nanomaterial release and subsequent alteration in the environment

Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement

Tuning dual-drug release from composite scaffolds for bone regeneration

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