Modeling and analysis of nature‐inspired branched micropillars for enhanced dynamic bio‐sensing

Abstract

Research evidence abounds on the effectiveness of micropillar‐based microelectromechanical systems for the detection of a wide variety of ultrasmall biological objects for clinical and non‐clinical applications. However, the standard micropillar‐based sensing platforms rely on a single‐column micropillar with a spot at the tip for binding of objects. Although this long‐standing form has shown immense potential, performance improvement is hindered by the fundamental limits enforced by physical laws. Moreover, the single‐column micropillar has a lower sensing area and is ill‐suited for a simultaneous differential sensing of chemical/biological objects of different mass. Here, we report a new set of nature‐inspired, branched micropillar‐based sensing resonators to address the highlighted issues. The characteristics of the newly proposed branched micropillars are comprehensively examined with three payloads (Bartonella Bacilliformis, Escherichia coli, and Micro magnetic beads). Anchored on the capability of continuum theoretical framework, the mathematical model of the micropillar is formulated through the synthesis of the modified couple stress, the Rayleigh‐Love, and the Timoshenko theories. The finite element method is employed to shed light on the variability of the structures' resonant response under performance reduction factors (payload's rotary inertia, damaged substrate, and density of a surrounding fluid). The results obtained indicate superior performance indicators for the triply‐branched micropillar: enhanced response sensitivity for multiple payloads and less susceptibility to deterioration in resonant frequencies due to fluid immersion.