The article describes the technology of chitosan-based matrix creation, and results of the study of its affine properties to bacterial lipopolysaccharide in aerosol dispersion. High degree of deacylation of polymer (over 97%), three-dimensional-porous structure, and multilayer packaging in analytical cartridge were the features of this matrix. Specified air volume, containing aerosol concentration of bacterial lipopolysaccharide, was passed through the glass cylinder with analytical container. The share of captured molecules ranged from 1.0% to 1.5%, demonstrating the efficiency of chitosan matrix. It is suitable for the creation of the devices for bacterial lipopolysaccharide detection in the air, based on the obtained matrix.