Modeling acetylcholine esterase inhibition resulting from exposure to a mixture of atrazine and chlorpyrifos using a physiologically-based kinetic model in fish

Mit, Corentin; Tebby, Cléo; Gueganno, Tristan; Bado‐Nilles, Anne; Beaudouin, Rémy

doi:10.1016/j.scitotenv.2020.144734

Cited by 19 publications

(8 citation statements)

References 67 publications

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“…The results were in agreement with the above, namely that the two most sold OPPs in the area of interest were chlorpyrifos and dimethoate [ 50 ]. However, since 1 April 2020, the European Union (EU) banned the marketing of pesticides containing chlorpyrifos, due to its potential genotoxicity and developmental neurotoxicity [ 39 ], and also because, as stated by Mit et al, the mechanisms of the low-dose effects of this substance as single chemicals and in a mixture are still unclear [ 72 ]. Therefore, the highest concentrations detected in WDP for chlorpyrifos were presumably due to its frequent use in the past for multiple applications, including agriculture; just consider that in 2016 it was one of the most frequently detected pesticides in fruit and vegetable samples taken in several southern European countries [ 51 , 65 ].…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, on dimethoate, the EU issued a non-renewal report in 2019, but it is still authorized at national levels and used in many European and non-European countries, mainly on vegetable crops and in olive oil production [ 38 , 70 , 71 ]. In addition, the presence of tolclofos-methyl, diazinon, pirimiphos-methyl, and malathion could probably be due to their known past use in crop protection [ 72 ]. Compared to previous studies, the concentrations found in the WDP samples of the Sele River were higher than those found in the dissolved phase of the Ebro River (Spain) by Gòmez-Gutiérrez et al [ 65 ] for diazinon (0.2–1.7 ng L −1 ), but lower than those detected for chlorpyrifos (n.d.—42.5 ng L −1 ).…”

Section: Resultsmentioning

confidence: 99%

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Occurrence, Distribution, and Risk Assessment of Organophosphorus Pesticides in the Aquatic Environment of the Sele River Estuary, Southern Italy

Montuori

Rosa

Duca

et al. 2022

Toxics

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The intensive use of organophosphorus pesticides (OPPs) causes concern among authorities in different countries, as many of them, remaining unchanged for a long time, pose a threat to environmental sustainability. This study assessed the spatio-temporal trends of nine OPPs in the water dissolved phase (WDP), suspended particulate matter (SPM), and sediment samples from the Sele River estuary, Southern Italy. Samples were collected in 10 sampling sites during four seasons. The highest levels were found at the mouth (mean value 28.25 ng L−1 as WDP + SPM) and then decreased moving southwards to the Mediterranean Sea. Moreover, highest concentrations were detected in the warm season (July) with a mean value of 27.52 ng L−1. The load contribution to the Mediterranean Sea was evaluated in about 61.5 kg year−1, showing that the river was an important source of OPPs through discharge into the sea. The risk assessment revealed that no high-risk indices for the general-case scenario were observed, but for the worst-case scenario, potential risks were associated with chlorpyrifos, pyrimifos-methyl, and parathion, suggesting that OPP contamination should not be neglected. This study makes up the first record of OPPs in the surface waters of the Sele River and provides helpful data as a starting point for future studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Occurrence, Distribution, and Risk Assessment of Organophosphorus Pesticides in the Aquatic Environment of the Sele River Estuary, Southern Italy

Montuori

Rosa

Duca

et al. 2022

Toxics

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“…The concentration of triazine herbicides were exceeding the maximum allowable concentration in drinking water and in the plow soil layer (Sraka et al, 2007). As herbicides such as atrazine and simazine are known to inhibit AChE and CES (Mit et al, 2021; Mladenović et al, 2018), these findings may explain significantly lower activities in Podunavlje and Donje Podravlje sites. These areas are known for the extensive practice of intensive agriculture and farming leading to pesticide and fertilizer pollution (Romić et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Blood biomarkers in white stork (Ciconia ciconia) nestlings show different responses in several areas of Croatia

et al. 2022

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White stork nestlings can provide quantitative data on the quality of the environment, as they are dependent on their parents that provide locally foraged food. Blood was sampled from the brachial vein (n = 109) and the sampling was performed in parallel with ringing during breeding season 2020 from five areas in eastern Croatia: Lonjsko polje, Jelas polje, Slavonski Brod–east, Podunavlje, and Donje Podravlje. In the present study, for the first time in Croatia, the following enzymatic biomarkers were assessed in white stork nestlings: activities of acetylcholinesterase (AChE), carboxylesterase (CES), glutathione S‐transferase (GST), and glutathione reductase (GR), as well as nonenzymatic biomarkers: levels of glutathione (GSH) and reactive oxygen species (ROS). All endpoints were measured in two blood fractions: plasma and a postmitochondrial fraction (S9). Nestlings from Podunavlje and Donje Podravlje, areas known for intensive agriculture, showed lower AChE and CES activity when compared to the other investigated areas, indicating the presence of inhibitory xenobiotics. Higher oxidative stress was observed in Slavonski Brod–east, an area surrounded by metal and engineering industry, and Podunavlje compared to the other sampling areas. Hence, this study shows the impact of pollutants from the surrounding metal, petroleum, and agricultural industry might have on the biomarkers in white stork nestlings, which are often seen as early‐warning signals.

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“…when exposed to these articles for a long time, the absorbed nano silver particles will cause indelible damage to the body's liver, kidney and other metabolic organs. Although nano silver may cause greater ecological toxicity than metallic silver in some cases, nano silver particles can enter the water environment through various ways and have potential adverse effects on the marine ecological environment [15], there are few reports on the marine ecological toxicity of nano silver at present, and it is impossible to conduct dose analysis on the marine nano silver pollution, and the relevant toxicity mechanism is still unknown, There is an urgent need to study the mechanism of its toxicity.…”

Section: 1nano Silvermentioning

confidence: 99%

Evaluation of the Inhibitory Effect of Nano Silver on Aquatic Organisms

2020

AJEB

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Nano silver has been widely used in various consumer products in recent years because of its excellent antibacterial properties. However, nano silver will inevitably enter the water during the production and consumption of related products. Many literatures have studied the aquatic toxicity of nano silver, but the research mainly focuses on the toxic effects of water exposure. There are few studies on the dietary exposure toxicity of nano silver. The aquatic toxicity results and mechanism are not clear, which is not conducive to the environmental risk assessment of nano silver. In this paper, by studying the effects of nano silver on the growth, reproduction, bioaccumulation and other indicators of Daphnia magna under the water exposure (nano silver), combined with the blank control experiment, the toxic mechanism of nano silver on Daphnia magna was analyzed, so as to provide more accurate toxicity data for the environmental water risk assessment of nano silver.

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Modeling acetylcholine esterase inhibition resulting from exposure to a mixture of atrazine and chlorpyrifos using a physiologically-based kinetic model in fish

Cited by 19 publications

References 67 publications

Occurrence, Distribution, and Risk Assessment of Organophosphorus Pesticides in the Aquatic Environment of the Sele River Estuary, Southern Italy

Occurrence, Distribution, and Risk Assessment of Organophosphorus Pesticides in the Aquatic Environment of the Sele River Estuary, Southern Italy

Blood biomarkers in white stork (Ciconia ciconia) nestlings show different responses in several areas of Croatia

Evaluation of the Inhibitory Effect of Nano Silver on Aquatic Organisms

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