Modelagem Computacional de um Veículo Elétrico para Competição de Eficiência Energética

Faria, Júlio B.; Toledo, Jose A.; Barbosa, Társis Prado

doi:10.48011/asba.v2i1.1369

Cited by 2 publications

(3 citation statements)

References 2 publications

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“…The CNTs was observed to trigger strong CD4 + and CD8 + Tcell mediated immune response. 111 For efficient anticancer vaccine delivery, Ovalbumin (OVA) peptide is surface functionalized on the multiwalled carbon nanotube along with the other components such as NY-ESO-1 as antigen and CpG oligonucleotides (CpG-ODNs), a TLR9 agonist. These nanoparticles successfully internalized into the dendritic cells which further decreased the tumor development and increased the survival of the mice in vivo.…”

Section: Nanoparticles As Peptide Drug Carriersmentioning

confidence: 99%

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Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies

Buddhiraju,

Yadav,

Dey

et al. 2023

ACS Appl. Bio Mater.

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Peptides are ideal biologicals for targeted drug delivery and have also been increasingly employed as theranostic tools in treating various diseases, including cancer, with minimal or no side effects. Owing to their receptor-specificity, peptidemediated drug delivery aids in targeted drug delivery with better pharmacological biodistribution. Nanostructured self-assembled peptides and peptide−drug conjugates demonstrate enhanced stability and performance and captivating biological effects in comparison with conventional peptides. Moreover, they serve as valuable tools for establishing interfaces between drug carriers and biological systems, enabling the traversal of multiple biological barriers encountered by peptide−drug conjugates on their journeys to their intended targets. Peptide-based drugs play a pivotal role in the field of medicine and hold great promise for addressing a wide range of complex diseases such as cancer and autoimmune disorders. Nanotechnology has revolutionized the fields of medicine, biomedical engineering, biotechnology, and engineering sciences over the past two decades. With the help of nanotechnology, better delivery of peptides to the target site could be achieved by exploiting the small size, increased surface area, and passive targeting ability of the nanocarrier. Furthermore, nanocarriers also ensure safe delivery of the peptide moieties to the target site, protecting them from degradation. Nanobased peptide delivery systems would be of significant importance in the near future for the successful targeted and efficient delivery of peptides. This review focuses on peptide−drug conjugates and nanoparticle-mediated self-assembled peptide delivery systems in cancer therapeutics.

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Section: Nanoparticles As Peptide Drug Carriersmentioning

confidence: 99%

“…These nanoparticles successfully internalized into the dendritic cells which further decreased the tumor development and increased the survival of the mice in vivo. 111…”

Section: Nanoparticles As Peptide Drug Carriersmentioning

confidence: 99%

Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies

Buddhiraju,

Yadav,

Dey

et al. 2023

ACS Appl. Bio Mater.

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“…So, in accordance with the changes in duty cycle, the mean voltage varies, controlling the motor speed. According to [52], the battery model used in the EV prototype can be defined by its state of charge (SOC) and its voltage V,…”

Section: Vehicle Dynamic Model and Performancementioning

confidence: 99%

A 3D-Printed Continuously Variable Transmission for an Electric Vehicle Prototype

2022

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This paper aims to present the design of a new 3D-printed continuously variable transmission (CVT) developed for an electric vehicle prototype competing in Shell Eco-marathon electric battery category, a world-wide energy efficiency competition sponsored by Shell. The proposed system is composed of a polymeric conic geared friction wheel assembled in the motor axle and directly coupled to the rear tire of the vehicle. The conical shape allows to implement a continuous variation of the geared friction wheel diameter in contact with the tire. The motor with the geared friction wheel was mounted over a board with linear bearings, allowing the speed ratio to change by moving the board laterally. A computational simulation model of a prototype electric vehicle with the proposed 3D-printed CVT was created in Matlab/Simulink environment to obtain the traction force in the geared friction wheel and also to analyze the vehicle performance. The simulation results demonstrated possibilities of increasing vehicle speed range output and available torque in the rear traction wheel. Also, it is shown with the simulated model that the designed CVT consumes 10.46% less energy than a fixed transmission ratio, demonstrating the CVT concept’s potential for battery consumption reduction. Lastly, a 3D-printing slicing software with an optimization algorithm plug-in was used to determine the best printing parameters for the conic geared friction wheel based on the tangential force, maximum displacement and safety factor. When compared to the original part with a 100% infill density, the optimized solution reduced the component mass by about 12% while maintaining safe mechanical resistance and stiffness.

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Modelagem Computacional de um Veículo Elétrico para Competição de Eficiência Energética

Cited by 2 publications

References 2 publications

Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies

Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies

A 3D-Printed Continuously Variable Transmission for an Electric Vehicle Prototype

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