2019
DOI: 10.1242/dev.177212
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Abstract: Hydra as a model system for regeneration

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Cited by 68 publications
(55 citation statements)
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References 113 publications
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“…This implies that the entire radial axis of the umbrella possesses the potential to form a manubrium, and that a control mechanism exists to prevent multiple manubria from forming. One explanation could be that Clytia manubrium has an organizing role, as is the case for the hypostome (mouth) of Hydra polyps (Bode, 2011;Meinhardt, 1993;Vogg et al, 2019), and provides an inhibitory signal that spreads through the umbrella and prevents the induction of additional manubria. We tested this hypothesis by grafting supernumerary manubria at different subumbrellar positions.…”
Section: Why Does Only One Manubrium Usually Regenerate?mentioning
confidence: 99%
See 1 more Smart Citation
“…This implies that the entire radial axis of the umbrella possesses the potential to form a manubrium, and that a control mechanism exists to prevent multiple manubria from forming. One explanation could be that Clytia manubrium has an organizing role, as is the case for the hypostome (mouth) of Hydra polyps (Bode, 2011;Meinhardt, 1993;Vogg et al, 2019), and provides an inhibitory signal that spreads through the umbrella and prevents the induction of additional manubria. We tested this hypothesis by grafting supernumerary manubria at different subumbrellar positions.…”
Section: Why Does Only One Manubrium Usually Regenerate?mentioning
confidence: 99%
“…The relative contributions of cell proliferation and tissue remodeling to the restoration of form vary widely among regenerating species. In the classic regeneration model Hydra, as in Clytia, body regeneration mainly involves remodeling and repatterning of existing tissues (Bode, 2003;Vogg et al, 2019). In contrast, cell proliferation plays a prominent role during regeneration of Nematostella and Hydractinia polyps (Amiel et al, 2015;Bradshaw et al, 2015;Passamaneck and Martindale, 2012).…”
Section: Distinct Cell Behaviors Coordinated In Time and Spacementioning
confidence: 99%
“…In the eighteenth century, Abraham Trembley (1719–1784) discovered regeneration in the hydra, which can recreate complete structures each time from bisected parts of the body 1 . Now, we know that some species from certain taxonomic groups, such as cnidarians, planarians, annelids and colonial ascidians, can undergo whole body regeneration and show no limitations of regeneration after recurrent fragmentations 2 5 . Among vertebrates, the concept of unlimited organ regeneration has been explored in several species.…”
Section: Introductionmentioning
confidence: 99%
“…These then polarize and transform into fully functional hydra 1 , albeit smaller than the adult consisting of about 100.000 cells. Hydra represents a well-known model organism for its remarkable regenerative properties 2 . Regrowth from a spheroid requires de-novo axis definition 3,4 .…”
Section: Introductionmentioning
confidence: 99%