Model Studies on the Antioxidant Activity of Common Terpenoid Constituents of Essential Oils by Means of the 2,2-Diphenyl-1-picrylhydrazyl Method

Wojtunik, Karolina; Cieśla, Łukasz; Waksmundzka‐Hajnos, Monika

doi:10.1021/jf502857s

Cited by 91 publications

(84 citation statements)

References 32 publications

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“…The monoterpene alcohols geraniol and lavandulol are weaker antioxidants than thymol, geraniol being more potent than lavandulol . The higher antioxidant potency of geraniol compared to lavandulol is due to fact that geraniol may lose allylic hydrogens thus neutralizing free radicals . The stronger antioxidant effects exhibited by T. citriodorus ‘Aureus’ EO may be attributed, in large part, to its higher content in geraniol (60.31% vs .…”

Section: Resultsmentioning

confidence: 99%

“…32 The higher antioxidant potency of geraniol compared to lavandulol is due to fact that geraniol may lose allylic hydrogens thus neutralizing free radicals. 33 The stronger antioxidant effects exhibited by T. citriodorus 'Aureus' EO may be attributed, in large part, to its higher content in geraniol (60.31% vs. 31.45% in T. vulgaris 'Faustini' EO) and aromatic compounds (7.54% vs. 0.35% in T. vulgaris 'Faustini' EO) ( Table 1). Geraniol, an acyclic monoterpene alcohol, showed strong DPPH scavenging activity; in addition, in cell-based assays, it reduced the lipid peroxidation and generation of reactive species (nitric oxide, reactive oxygen species) and increased the glutathione level and superoxide dismutase activity.…”

Section: Antioxidant Activitymentioning

confidence: 95%

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Essential oils of Moldavian Thymus species: Chemical composition, antioxidant, anti‐Aspergillus and antigenotoxic activities

Aprotosoaie

Ciocârlan

Brebu³

et al. 2019

Flavour & Fragrance J

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Thymus species are important aromatic, medicinal and culinary plants with a significant economic value. This study evaluated for the first time the chemical composition and in vitro bioactivities of the essential oils (EOs) from five Moldavian Thymus species (T. vulgaris, T. × citriodorus, T. calcareus) and cultivars (T. vulgaris ‘Faustini’, T. citriodorus ‘Aureus’). The main compounds in Thymus EOs were: thymol in T. vulgaris and T. calcareus EOs (55.44% and 55.45%, respectively), lavandulol in T. × citriodorus EO (54.27%), and geraniol in T. citriodorus ‘Aureus’ and T. vulgaris ‘Faustini’ EOs (60.31% and 31.45%, respectively). T. vulgaris and T. calcareus EOs showed the most potent antioxidant activities (EC50=0.003 mg/mL in ABTS radical cation scavenging assay) and exhibited significant inhibitory effects against aflatoxin‐producing Aspergillus flavus fungus (MIC=0.25 μL/mL). At doses that provided micromolar concentrations of thymol, T. vulgaris and T. calcareus EOs acted genoprotective at preventive and interventional levels against H2O2‐induced genomic damage in V79 cells, the former being more active (6.21% and 5.52% vs. 25.13% and 7.26% tail DNA in pre‐ and post‐treatment protocols, respectively). The genoprotective effects may be ascribed to antioxidant potential and, possibly, to stimulation of DNA repair processes. The Moldavian Thymus species are valuable resources of bioactive EOs for pharmaceutical and food industries (T. vulgaris, T.calcareus) but also for flavor industry and perfumery (T. × citriodorus, T. citriodorus ‘Aureus’, T. vulgaris ‘Faustini’).

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Section: Resultsmentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 95%

Essential oils of Moldavian Thymus species: Chemical composition, antioxidant, anti‐Aspergillus and antigenotoxic activities

Aprotosoaie

Ciocârlan

Brebu³

et al. 2019

Flavour & Fragrance J

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“…Monoterpenes are not typically considered as potent radical scavengers. Therefore, a moderate antioxidant activity of EO can be possibly attributed to the relative high percentage of monoterpenes present in EO (Wojtunik et al 2014).…”

Section: Antioxidant Activitiesmentioning

confidence: 99%

Chemical composition, antioxidant and antibacterial properties of Bene (Pistacia atlantica subsp. mutica) hull essential oil

et al. 2015

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The tree Pistacia atlantica subsp. mutica, namely Bene, is widely distributed in Iranian mountains. Recent studies revealed that the oil of Bene was stable, even more stable than sesame oil, with antioxidant properties. This can give versatile applications for the oil. The volatile composition of this oil has not chemically been investigated so far. In this study, sixty three compounds were identified in the essential oil (EO) of Bene hull. The major components were determined to be α-pinene (20.8 %), camphene (8.4 %), β-myrcene (8.2 %) and limonene (8 %). Antioxidant activities of the essential oil from Bene hull were evaluated by using 2, 2′-diphenyl-1-picrylhydrazyl (DPPH) free radical-scavenging, ferric reducing antioxidant power (FRAP), β-carotene bleaching test, thiobarbituric acid reactive species (TBARS) and Rancimat assays. The Bene essential oil exhibited significant antioxidant activities in FRAP and TBARS assays as compared with positive controls. In addition, the oil was evaluated for its antimicrobial activity against both Gram positive (Staphylococcus aureus) and Gram negative (Escherichia coli) bacteria. It showed significant antibacterial activities against S. aureus and E. coli with minimum inhibitory concentration (MIC) values of 6 and 12.5 μg/mL, respectively.

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“…The IC 50 value of the moss terpenoid extract was at 35µg/ml while that of ascorbate was at 22 µg/ml. Wojtunik et al 17 proposed a model on the antioxidant potential of terpenoids constituents in 2,2-diphenyl-1-picrylhydrazyl method. Thoppil et al 18 reviewed the role of terpenoids as chemopreventive and therapeutic against liver cancer.…”

Section: +mentioning

confidence: 99%

Antioxidant Activities of Terpenoids from Thuidium tamariscellum (C. Muell.) Bosch. and Sande-Lac. a Moss

Mohandas¹,

Murugan²

2018

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Introduction:Thuidium tamariscellum is a small creeping epiphytic moss growing on trunks and branches of trees as well as on moist shady rocky surface at high altitudes areas. Methods: The present study was undertaken to analyze the phytochemicals in the species and its antioxidant potentialities interms of DPPH, ABTS, H 2 O 2 , FRAP and metal chelating ability. Results: Total terpenoids level was remarkable. Interestingly, a concentration dependent free radical scavenging potential was noticed and was comparable with the synthetic antioxidant ascorbate. Further, the FTIR analysis of petroleum ether, chloroform, ethyl acetate, and methanol extract confirmed the presence of alcohols/phenols, primary, secondary amines, amides, alkanes, aldehydes, saturated aliphatic alkenes aromatics and aromatic amines, nitro compounds, carboxylic acids, esters, ethers, aliphatic amines, alkyl halides and carbonyls in the moss indicating the presence of medicinally important compounds like flavonoids, terpenoids and alkaloids in the various solvent extracts of the moss. Conclusion: The overall result of the present study showed that the moss is rich in important pharmaceutical compounds and was reflected as its antioxidant potential. Further studies are warranted to isolate, identify and purify the lead terpenoid present in the moss.

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Model Studies on the Antioxidant Activity of Common Terpenoid Constituents of Essential Oils by Means of the 2,2-Diphenyl-1-picrylhydrazyl Method

Cited by 91 publications

References 32 publications

Essential oils of Moldavian Thymus species: Chemical composition, antioxidant, anti‐Aspergillus and antigenotoxic activities

Essential oils of Moldavian Thymus species: Chemical composition, antioxidant, anti‐Aspergillus and antigenotoxic activities

Chemical composition, antioxidant and antibacterial properties of Bene (Pistacia atlantica subsp. mutica) hull essential oil

Antioxidant Activities of Terpenoids from Thuidium tamariscellum (C. Muell.) Bosch. and Sande-Lac. a Moss

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