Model selection reveals selective regulation of blood amino acid and lipid metabolism by insulin in humans
Suguru Fujita,
Ken-ichi Hironaka,
Yasuaki Karasawa
et al.
Abstract:Insulin plays a crucial role in regulating the metabolism of blood glucose, amino acids, and lipids in humans. However, the mechanisms by which insulin selectively controls these different metabolites are not yet fully understood. To address this question, we used mathematical modeling to identify the selective regulatory mechanisms of insulin on blood amino acids and lipids. Our study revealed that insulin negatively regulates the influx and positively regulates the efflux of lipids, which is consistent with … Show more
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