Model Reactions for Synthesis of Pharmacologically Active Polymers by Way of Monomeric and Polymeric Reactive Esters

Batz, Hans‐Georg; Franzmann, Giselher; Ringsdorf, Helmut

doi:10.1002/anie.197211031

Cited by 122 publications

(95 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1] The nucleophilic substitution of polymeric active esters has become the most common form of post-polymerization modification since the introduction of these polymers by the groups of Ferruti [2] and Ringsdorf. [3] Polymeric active esters can be obtained from a variety of monomers using both (controlled) radical polymerization as well as metal-catalyzed polymerization techniques ( Table 1). The most common monomers used to prepare side-chain N-hydroxysuccinimide (NHS) ester polymers are NMAS and NAS.…”

Section: Modification Of Polymeric Active Estersmentioning

confidence: 99%

Synthesis of Functional Polymers by Post‐Polymerization Modification

2008

View full text Add to dashboard Cite

Post-polymerization modification is based on the direct polymerization or copolymerization of monomers bearing chemoselective handles that are inert towards the polymerization conditions but can be quantitatively converted in a subsequent step into a broad range of other functional groups. The success of this method is based on the excellent conversions achievable under mild conditions, the excellent functional-group tolerance, and the orthogonality of the post-polymerization modification reactions. This Review surveys different classes of reactive polymer precursors bearing chemoselective handles and discusses issues related to the preparation of these reactive polymers by direct polymerization of appropriately functionalized monomers as well as the post-polymerization modification of these precursors into functional polymers.

show abstract

Section: Modification Of Polymeric Active Estersmentioning

confidence: 99%

Synthesis of Functional Polymers by Post‐Polymerization Modification

2008

View full text Add to dashboard Cite

show abstract

“…[14][15][16][17][18] Ringsdorf and coworkers 19 and Ferruti et al 20 performed pioneering work on reactive polymers based on activated esters in 1972. Since their first report, polymeric activated esters have found broad applications that reached far beyond simple polymer chemistry into materials and life science.…”

Section: Polymeric Activated Estersmentioning

confidence: 99%

Synthesis of well‐defined polymeric activated esters

Théato

2008

J. Polym. Sci. A Polym. Chem.

276

260

View full text Add to dashboard Cite

Monomers bearing an activated ester group can be polymerized under various controlled polymerization techniques, such as ATRP, NMP, RAFT polymerization, or ROMP. Combining the functionalization of polymers via polymeric activated esters with these controlled polymerization techniques generate possibilities to realize highly functionalized polymer architectures. Within this highlight two different research areas of activated esters in polymer science will be discussed: (i) the preparation of defined reactive polymer architectures by controlled polymerization techniques and (ii) the preparation of defined reactive thin films. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 6677–6687, 2008

show abstract

“…25 The ligand, N-(n-propyl)-2-pyridylmethanamine, was prepared as described elsewhere. 26 The ATRP of SucMA onto nanoparticles surface was carried out by modifying the reported process.…”

Section: Synthesis Of Magnetite Nanoparticles With Atrp Initiatormentioning

confidence: 99%