This paper proposes a control strategy for active lateral secondary suspension that uses preview data. Based on a derived analytical model, a model predictive controller (MPC) is implemented. The influence of the track irregularities upon carbody lateral dynamics is considered explicitly. The controller developed is applied to a full-scale rail vehicle model. Ride comfort is evaluated according to EN 12299. Multibody simulations show that there is a significant increase in continuous ride comfort on poor-quality tracks.