Model predictions of myoelectrical activity of the small bowel

Abstract

A mathematical model for the periodic electrical activity of a functional unit of the small intestine is developed. Based on real morphological and electrophysiological data, the model assumes that: the functional unit is an electromyogenic syncytium; the kinetics of L, T-type Ca2+, mixed Ca(2+)-dependent K+, potential sensitive K+ and Cl- channels determines electrical activity of the functional unit; the basic neural circuit, represented by a single cholinergic neurone, provides an excitatory input to the functional unit via receptor-linked L-type Ca2+ channels. Numerical simulation of the model has shown that it is capable of displaying the slow waves and that slight modifications of some of the parameters result in different electrical responses. The effects of the variations of the main parameters have been analyzed for their ability to reproduce various electrical patterns. The results are in good qualitative and quantitative agreement with results of experiments conducted on the small intestine.

A biophysically constrained computational model of the action potential of mouse urinary bladder smooth muscle

“…Such models have furnished a wealth of insight into the fundamental mechanisms underlying electrical excitability. So far, models for a few smooth muscle cell types, incorporating ionic channels and calcium dynamics, have been developed, such as for intestinal [ 26 ], uterine [ 27 , 28 , 29 ], jejunal [ 30 ], gastric [ 31 , 32 ], mesenteric [ 33 ], small bowel [ 34 ] and arterial [ 35 , 36 ] smooth muscle cells.…”

Dynamics of intestinal propulsion

“…Accuracy of the numerical algorithm and robustness of the platform have been evaluated extensively through multiple numerical experiments (different levels of discretization and time steps of integration, etc.) and the variation of parameters and constants of the model Fedotov, 2004, 2005;Miftakhov and Vannier, 2002;Miftakhov et al, 1989Miftakhov et al, , 1996Miftakhov et al, , 1997. A Demo version of the program for a limited personal use can be obtained from the company's website on: www.aincompany.com or upon a request on: rmif@amath.kaist.ac.kr.…”

“…All considerations presented below are in the frame of an earlier developed mathematical model and only a brief description of the basic biological and mathematical concepts involved is provided. The reader is advised to consult our previous publications on this matter for full details (Miftakhov and Vannier, 2002;Miftakhov et al, 1996Miftakhov et al, , 1999Miftakhov, 1989Miftakhov, , 1997.…”

Biophysical Mechanisms of Vaginal Smooth Muscle Contraction: The Role of the Membrane Potential and Ion Channels

“…Computational modeling offers a powerful approach to studying vaginal smooth muscle contraction, allowing researchers to simulate and analyze complex physiological processes with precision. There are a lot of computational models established for different types of smooth muscle electrophysiology [ 15 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 ]. By integrating experimental data and physiological parameters, these models can elucidate the underlying mechanisms governing smooth muscle function in the vaginal wall.…”