Model of Impedance Changes in Unmyelinated Nerve Fibers

Tarotin, Ilya; Aristovich, Kirill; Holder, David

doi:10.1109/tbme.2018.2849220

Cited by 23 publications

(71 citation statements)

References 47 publications

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“…Similar impedance changes occur in unmyelinated nerve and have been demonstrated in the walking leg nerve of the crab 46 . The frequency for recording these is different and probably optimal at 225 Hz 47 . A challenge of EIT of these fibers is dispersion-the impedance change may become vanishingly small at >10 cm from the initiation site.…”

Section: Discussionmentioning

confidence: 99%

Imaging fascicular organization of rat sciatic nerves with fast neural electrical impedance tomography

et al. 2020

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Imaging compound action potentials (CAPs) in peripheral nerves could help avoid side effects in neuromodulation by selective stimulation of identified fascicles. Existing methods have low resolution, limited imaging depth, or are invasive. Fast neural electrical impedance tomography (EIT) allows fascicular CAP imaging with a resolution of <200 µm, <1 ms using a non-penetrating flexible nerve cuff electrode array. Here, we validate EIT imaging in rat sciatic nerve by comparison to micro-computed tomography (microCT) and histology with fluorescent dextran tracers. With EIT, there are reproducible localized changes in tissue impedance in response to stimulation of individual fascicles (tibial, peroneal and sural). The reconstructed EIT images correspond to microCT scans and histology, with significant separation between the fascicles (p < 0.01). The mean fascicle position is identified with an accuracy of 6% of nerve diameter. This suggests fast neural EIT can reliably image the functional fascicular anatomy of the nerves and so aid selective neuromodulation.

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Section: Discussionmentioning

confidence: 99%

Imaging fascicular organization of rat sciatic nerves with fast neural electrical impedance tomography

et al. 2020

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“…These equations were adapted to human C fibers by reducing the resistivity, fiber diameter, etc. according to the experimental results in [42,43]. Equation 1shows the change in transmembrane current by external stimulation.…”

Section: Computational Models Of C and Aδmentioning

confidence: 99%

A Simulation Study on Selective Stimulation of C-Fiber Nerves for Chronic Pain Relief

Yoshida

Tripanpitak

et al. 2020

IEEE Access

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It has been reported that stimulating nociceptive unmyelinated C nerves (C) near the sarcolemma could induce the secretion of endogenous opioids that relieve chronic pain. However, a substantial concern remains: concomitant stimulation might cause acute pain to nociceptive myelinated Aδ nerves (Aδ), which generally have a lower activation threshold than the C. However, few studies have reported on C selectivity over Aδ (C-selectivity). In this study, the C and Aδ nerves were modeled using the Hodgkin-Huxley (HH) and McIntyre-Richardson-Grill (MRG) models, respectively. Two potential stimulation schemes, including bipolar square waves and burst modulated alternating current, together with a new stimulation scheme named inhibit-Aδ (i-Aδ) that inhibits the excitability of the Aδ, were systematically investigated. Their stimuli were given to the C and Aδ nerves through point electrodes located near the nerve fibers. Simulation results revealed that i-Aδ presented the highest C-selectivity, which provides a basis for non-invasive effective chronic-pain relief.

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“…When ion channels open, the current can flow into the intracellular compartment which provides an additional conducting medium (Keynes and Lewis, 1951;Tarotin et al, 2018). The magnitude of the impedance change varies with frequency.…”

Section: Resolutionmentioning

confidence: 99%

Optimisation of bioimpedance measurements of neuronal activity with an ex vivo preparation of Cancer pagurus peripheral nerves

Smith

Kelly

Avery

et al. 2019

Journal of Neuroscience Methods

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Highlights • Physiological parameters for the crab walking leg nerve model of an unmyelinated fibre were optimised resulting in improved nerve health. • Developed protocol to combine state-of-the-art bioimpedance measurement methods with previously reported unmyelinated fibre recording methods. • Measurement made with the optimised method and recording interface obtained single trace SNR ratios of ³ 3:1, which resulted in a 10-trace average of an SNR of ³ 9:1 • Demonstrated two methods in which to ascertain if the measured bioimpedance change is a genuine CAP dependent signal.

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Model of Impedance Changes in Unmyelinated Nerve Fibers

Abstract: The accurate realistic model of unmyelinated nerve allows optimisation of EIT parameters and matches literature and experimental results.

Cited by 23 publications

References 47 publications

Imaging fascicular organization of rat sciatic nerves with fast neural electrical impedance tomography

Imaging fascicular organization of rat sciatic nerves with fast neural electrical impedance tomography

A Simulation Study on Selective Stimulation of C-Fiber Nerves for Chronic Pain Relief

Optimisation of bioimpedance measurements of neuronal activity with an ex vivo preparation of Cancer pagurus peripheral nerves

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