Model generation of coronary artery bifurcations from CTA and single plane angiography

Abstract

The authors have shown that fusion of CTA and CCA is feasible for realistic generation of coronary bifurcation models before and after PCI. The method proposed is efficient, and relies on minimal user interaction, and therefore is of high value to study geometric and hemodynamic changes of treated patients.

Fluid Flow at Branching Junctions

“…With regard to the experimental methods used to investigate the radius and angle branching laws, various imaging and measurement techniques, such as computed tomography scan, magnetic resonance imaging and confocal laser microscopy, as well as other acquisition techniques like polymer casting and cryo-microtome sectioning have been used to obtain geometric and topological information from biological branching networks [5,61,82,[94][95][96][97][98][99][100][101][102][103][104][105][106][107]. However, the majority of these techniques and their complementary analysis methods are susceptible to significant errors and hence cannot provide accurate geometrical data to test the validity of the branching rules such as Murray's law.…”

Topologic and Hemodynamic Characteristics of the Human Coronary Arterial Circulation

“…Available anatomical studies address specific research questions and provide only limited data that do not allow a translation toward global coronary hemodynamics. This includes the vascularization of the anterior papillary muscle, perfused by the LCA versus RCA (Zajaczkowski et al, 2018), the impact of branching on wave propagation (Rivolo et al, 2016), the effect of side branches on coronary flow (Wiwatanapataphee et al, 2012), and branching patterns of only the large coronary arteries (Hutchins et al, 1976;Seiler et al, 1992;van der Waal et al, 2009;Schoenenberger et al, 2012;Cardenes et al, 2013;Gupta et al, 2013;Medrano-Gracia et al, 2017;Ormiston et al, 2018). In an initial study, we analyzed the presence of collateral connections within and between the perfusion territories in the human heart .…”