The combined effects of chemical reaction, radiation, Dufour and Soret effects on Casson MHD fluid flow over a vertical plate with heat source/sink has been studied with constant velocity, variable temperature and concentration. The governing equations of the flow have been solved by using the finite difference method. The effects of various parameters on velocity, temperature and concentration fields are studied with the help of graphs. It is found that velocity decreased with the increase of Casson parameter, Hartmann number, thermal conductivity, Schmidt number, Chemical parameter and decrease of Soret effect, Thermal Grashof number and Mass Grashof number. Concentration found to be decreasing with the decrease of Soret number and increasing chemical parameter. Temperature decreased when thermal radiation is increased and heat source is decreased.