Model for end‐stage liver disease combined with serum prealbumin to predict the prognosis of patients with decompensated liver cirrhosis

Liu, Fei; Cai, Ling; Zhong, Li-Ye; Chen, Chi; Xu, Fei; Zhao, Zhi‐Xue; Chen, Xi Mei

doi:10.1111/j.1751-2980.2010.00465.x

Cited by 21 publications

(21 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In one study, comparing these models, UKELD and updated MELD were poor in predicting mortality compared to other 4 models. 132 Other factors shown to improve the MELD accuracy are HVPG, 133 von Willebrand factor level at a cut-off level of 315%, 134 persistent CRP levels of $29 mg/L, 135 prealbumin levels of >69 mg/L, 136 apoptosis marker CK-18. 137 Refinements to improve the accuracy of MELD would continue and until we find a better score, livers could continue to be allocated using the current MELD based system.…”

Section: Other Suggested Modificationsmentioning

confidence: 99%

Model for End-stage Liver Disease

Singal

Kamath

2013

Journal of Clinical and Experimental Hepatology

124

View full text Add to dashboard Cite

Section: Other Suggested Modificationsmentioning

confidence: 99%

Model for End-stage Liver Disease

Singal

Kamath

2013

Journal of Clinical and Experimental Hepatology

124

View full text Add to dashboard Cite

“…[11] AUC of MELD-Na of this study was found to be 0.70, which was relatively lower than that of other studies, of 0.85 to 0.92. [13,16,17] However, according the suggestion of Muller et al, [23] its diagnostic performance ranged from good-excellent. It would be attributable to its significantly longer follow-up period, of 14 years, than other studies of which follow-up periods were up to 20 months, and the relatively lower AUC of this study might be because it included data from even cases censored during the follow-up period in order to reduce bias in its results.…”

Section: Discussionmentioning

confidence: 99%

“…[12,13] Studies on the prognosis of patients with cirrhosis have been mostly focused on terminal cases and anticipation of short-term mortality, and most of them highlight the analysis of prognosis of patients with cirrhosis rather than classification of patients considering the level of severity. [14][15][16][17][18][19] Moreover, the analysis of prognostic factors for mortality of patients should include not only disease-related factors, but also personal and social factors. Such analysis could provide a comprehensive and systematic understanding of patients diagnosed with cirrhotic complications.…”

Section: Introductionmentioning

confidence: 99%

Analysis of mortality prognostic factors using model for end-stage liver disease with incorporation of serum-sodium classification for liver cirrhosis complications

Kim

Jang

2019

Medicine

View full text Add to dashboard Cite

Since the progression of cirrhosis is accelerated each time a complication recurs, the management and treatment of the complication is critical in enhancement of the quality of life and expectation of life in patients. The use of model for end-stage liver disease with incorporation of serum-sodium (MELD-Na) with physiological indicators can be used to assess severity and differentiate therapeutic interventions.This study is aimed to determine the mean survival period and cumulative survival rate by classifying patients into high-risk and lowrisk groups based on MELD-Na, a predictor of mortality in liver disease, and to investigate the mortality prognostic factors.A retrospective cohort study, which follows the STROBE checklist, was performed. 263 patients who were diagnosed with liver cirrhosis complications for the first time and hospitalized were selected as the subjects of this study. The collected data were analyzed based on the survival package provided by the statistical program R version 3.4.2.Subjects were classified into high-risk and low-risk groups using MELD-Na 14 points where sensitivity and specificity crossed the cut-off point. Gender, age, and primary caregiver were significant variables in the mortality high-risk group, and AST, albumin, and primary caregiver were significant variables in the mortality low-risk group. Based on these mortality prognostic factors, it is possible to present the factors affecting mortality in patients who were diagnosed with liver cirrhosis complications for the first time. The classification of patients by risk level could be the foundation to provide accurate guidelines for management and it is necessary to modify prognostic factors and apply nursing interventions to manage complications.Abbreviations: AST = aspartate transferase, MELD-Na = model for end-stage liver disease with incorporation of serum-sodium.

show abstract

“…[41] Prealbumin is the earliest serum protein that is altered during conditions of acute malnutrition and is most sensitive toward normalization following nutritional supplementation. Prealbumin presents quite a small body reserve and a short half-life (of approximately 2 days).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of plasma leptin, tumor necrosis factor-α, and prealbumin as prognostic biomarkers during clinical recovery from acute exacerbations of chronic obstructive pulmonary disease

et al. 2017

View full text Add to dashboard Cite

Background:Inflammatory and nutritional biomarkers have an important bearing on outcomes of acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but the temporal profile of these compounds during an acute episode is unclear.Patients and Methods:Plasma leptin, prealbumin, and tumor necrosis factor-alpha (TNF-α) were estimated at baseline and before hospital discharge in patients with AECOPD.Results:A total of 82 patients were evaluated (66 males; mean (standard deviation) age, 61.6 (10.1) years. Of these, 74 subjects (90.2%) were current or former smokers, with median (range) pack-years of 15 (0–96), duration of COPD of 8 years (range, 2–25 years) and duration of current symptoms being 5 days (range, 1–30 days). Majority (41.5%) had type I (severe) exacerbation. During the current episode, 46 patients (58.9%) required mechanical ventilation for a median of 6 days (range, 1–34). The median duration of hospital stay was 13 days, (range, 1–110). At discharge, significant reduction was observed in dyspnea, total leukocyte count, erythrocyte sedimentation rate (ESR), partial pressure of carbon dioxide, hemoglobin, urea, creatinine, potassium, aspartate transferase, and TNF-α levels compared to baseline, whereas arterial pH, PO2, serum albumin, prealbumin, and leptin significantly improved. No difference was seen in leptin, prealbumin, and TNF-α between patients with mild/moderate and severe exacerbation, or between patients who required or did not require mechanical ventilation. Change in leptin correlated with body mass index and change in ESR; no associations were observed between leptin, prealbumin, and TNF-α with other clinico-laboratory variables.Conclusion:Plasma levels of novel inflammatory and nutritional biomarkers, i.e., leptin, TNF-α, and prealbumin are altered in AECOPD episodes and lag behind other parameters during recovery. These biomarkers are not reliable predictors of clinical outcomes in these patients.

show abstract

Model for end‐stage liver disease combined with serum prealbumin to predict the prognosis of patients with decompensated liver cirrhosis

Abstract: MELD score ≤ 18 combined with PA ≥ 70 mg/L could predict the 6-month and 1-year prognosis of patients with decompensated liver cirrhosis, and was superior to that of MELD score alone.

Cited by 21 publications

References 15 publications

Model for End-stage Liver Disease

Model for End-stage Liver Disease

Analysis of mortality prognostic factors using model for end-stage liver disease with incorporation of serum-sodium classification for liver cirrhosis complications

Evaluation of plasma leptin, tumor necrosis factor-α, and prealbumin as prognostic biomarkers during clinical recovery from acute exacerbations of chronic obstructive pulmonary disease

Contact Info

Product

Resources

About