Model for End-Stage Liver Disease (MELD) Score System to Evaluate Patients With Viral Hepatitis on the Waiting List: Better Than the Child-Turcotte-Pugh (CTP) System?

Cuomo, O.; Perrella, Alessandro; Arenga, G.

doi:10.1016/j.transproceed.2008.05.072

Cited by 17 publications

(15 citation statements)

References 11 publications

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“…This finding is in agreement with previous studies reporting same relationship but with higher correlation coefficient values [32][33][34].…”

Section: Discussionsupporting

confidence: 94%

“…This finding is in agreement with Schnider et al [40]. However, many previous studies reported a significant decrease in PFV as the cirrhosis progressed [27], and with increasing CTP grades of severity of cirrhosis [15,26]; however, the portal blood flow remained normal because of enlarged portal caliber [34]. Also, KoK et al [36] described a reversed portal flow in patients with veno-occlusive disease and portosystemic shunts; and a decrease in the PFV in cirrhotic patients.…”

Section: Discussionsupporting

confidence: 92%

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Correlation Between Sonographic Portal Vein Diameter and Flow Velocity With the Clinical Scoring Systems MELD and CTP in Cirrhotic Patients: Is There a Relationship?

Shateri

2012

Gastroenterology Research

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“…This finding is in agreement with previous studies reporting same relationship but with higher correlation coefficient values [32][33][34].…”

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Correlation Between Sonographic Portal Vein Diameter and Flow Velocity With the Clinical Scoring Systems MELD and CTP in Cirrhotic Patients: Is There a Relationship?

Shateri

2012

Gastroenterology Research

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“…Recently, the MELD score has replaced the CP score in the United States for prioritizing liver donor allocation. Como et al (39) showed that the use of the MELD score produced an advantage for Hepatocellular Carcinoma (HCC), but about one in every 11 viral hepatitis patients may be harmed using this scoring system. …”

Section: Discussionmentioning

confidence: 99%

Introducing an Optimal Liver Allocation System for Liver Cirrhosis Patients

et al. 2013

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BackgroundLiver transplantation (LT) is the only treatment option for patients with advanced liver disease. Currently, liver donation to these patients, considering priorities, is based on the Model for End-Stage Liver Disease (MELD). MELD score is a tool for predicting the risk of mortality in patients with advanced liver disease. However, few studies have so far been conducted in Iran on the efficacy of MELD score of these patients.ObjectivesThis study reviews the present status of the MELD score and introduces a new model for optimal prediction of the risk of mortality in Iranian patients with advanced liver disease.Patients and MethodsData required were collected from 305 patients with advanced liver disease who enrolled in a waiting list (WL) in Imam Khomeini Hospital from May 2008 to May 2009. All of the patients were followed up for at least 3 years until they died or underwent LT. Cox regression analysis was applied to select the factors affecting their mortality. Survival curves were plotted. Wilcoxson test and receiver operating characteristics curves for survival predictive model were used to compare the scores. All calculations were performed with the SPSS (version 13.0) and R softwares.ResultsDuring the study, 71 (23.3%) patients died due to liver cirrhosis and 43 (14.1%) underwent LT. Viral Hepatitis (43.7%) is the most common cause of end-stage liver disease among Iranian patients. A new model (NMELD) was proposed with the use of the natural logarithms of two blood serum variables (total bilirubin and albumin) and the patients' age (year) by applying the Cox model:NMELD = 10 × (0.736 × ln (bilirubin) – 1.312 × ln (albumin) + 0.025 × age + 1.776)ConclusionsThe results of the Wilcoxon test showed that there is a significant difference between the usual MELD and our proposed NMELD scores (P < 0.001). Receiver operating characteristics curve for survival predictive model indicated that the NMELD score is more efficient compared with the MELD score in predicting the risk of mortality. Since serum creatinine was not significant in NMELD score, further studies to clarify this issue are suggested.

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“…The INR has been accepted to standardize PT reporting in liver disease. However, kovacs [15] demonstrated that the INR system for patients with liver impairment is not valid.…”

Section: Discussionmentioning

confidence: 99%

“…The INR has been proposed [12] and is accepted routinely to standardize PT reporting in liver disease [12,[14][15][16][17], however, the ISIs used in the calculation of the INR is derived from a cohort of patients on stable oral anticoagulant, so the INR should only be applied to patients receiving stable oral anticoagulant therapy [18]. This is due to the difference in the mechanisms of the coagulation defects, in liver disease, most coagulation defects are caused by reduced synthesis of coagulation factors, whereas oral anticoagulation induces decarboxylated inactive protein production [19].…”

Section: Introductionmentioning

confidence: 99%

Comparison of modes of prothrombin time reporting in patients with advanced liver disease associated with viral hepatitis

Wei¹,

Zheng²,

Xiao³

et al. 2009

J Thromb Thrombolysis

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Model for End-Stage Liver Disease (MELD) Score System to Evaluate Patients With Viral Hepatitis on the Waiting List: Better Than the Child-Turcotte-Pugh (CTP) System?

Cited by 17 publications

References 11 publications

Correlation Between Sonographic Portal Vein Diameter and Flow Velocity With the Clinical Scoring Systems MELD and CTP in Cirrhotic Patients: Is There a Relationship?

Correlation Between Sonographic Portal Vein Diameter and Flow Velocity With the Clinical Scoring Systems MELD and CTP in Cirrhotic Patients: Is There a Relationship?

Introducing an Optimal Liver Allocation System for Liver Cirrhosis Patients

Comparison of modes of prothrombin time reporting in patients with advanced liver disease associated with viral hepatitis

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