An option being considered by current and prospective mobile satellite service (MSS) operators is the use of constellations of non‐geostationary orbit (NGSO) satellites to provide global personal communications. The scarcity of free spectrum, together with the bandwidth typically required, means that any new MSS system must consider sharing spectrum with other systems and services. Spectrum sharing must be based on defined interference criteria being satisfied. When multiple NGSO satellites are considered there is no accepted method for assessing interference. This paper describes a model used as the basis for a computer simulation of interference scenarios involving MSS, fixed service (FS) and fixed satellite service (FSS) systems. The simulation includes NGSO dynamics, constellations of MSS satellites with multi‐spot antennas, multiple geostationary FSS satellites and multiple hop FS links. Interference events are based on C/I calculations, and statistics, such as the percentage of time that the C/I falls below a required protection ratio, are calculated. More generally C/I cumulative distribution functions are produced.