Model fluids representing aqueous in-vitro diagnostic reagents for the development of dispensing systems

Losleben, Nadine; Spinke, J.; Adler, Sabrina; Oranth, Norbert; Zengerle, Roland

doi:10.1016/j.drudis.2013.06.011

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…6 The in vitro diagnostic (IVD) model to establish the fluid pattern enhances the droplet precision, producing high-quality biometric strips. 7 The uniformity of the reagent is correlated with injection valves and spray parameters. 8 The dispensing technology significantly affects the readings of the test piece; thus, a dual-voltage drive electromagnetic control system improves the dynamic characteristics of the injection valve and the firing speed and can apply a high-viscosity adhesive without preheating.…”

Section: Introductionmentioning

confidence: 99%

Effect of filling pressure in jetting dispenser on the performance of blood glucose test strips using immersion gold-plated printed circuit board

Kim

Chang

Lee

et al. 2018

Proc Inst Mech Eng H

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To ensure accurate glucose readings when dispensing glucose oxidase enzyme solution from a jetting dispenser onto glucose test strips fabricated from an immersion gold-plated printed circuit board, every drop of the enzyme solution needs to have nearly the same weight and to be dispensed on the reaction zone of the test strips. Experimental results in this study show that the filling pressure in the fluid reservoir containing the glucose enzyme solution to dispense onto the test strips significantly affect the glucose test results. A filling pressure of 12 psi produces test strips with lower coefficient of variation and standard deviation than 10 and 14 psi. Proper filling pressure for dispensing glucose enzyme onto glucose test strips needs to be determined for any enzyme compound formulation.

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Section: Introductionmentioning

confidence: 99%

Effect of filling pressure in jetting dispenser on the performance of blood glucose test strips using immersion gold-plated printed circuit board

Kim

Chang

Lee

et al. 2018

Proc Inst Mech Eng H

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“…The test fluids cover the typical range of viscosity (1.03–16.98 mPas) and surface tension (30.49–70.83 mN/m) of reagents used in the in vitro diagnostics. 31,37…”

Section: Introductionmentioning

confidence: 99%

“…Viscosity and surface tension of the liquid formulations range from 1.03 to 16.98 mPas and 30.49 to 70.83 mN/m (at 20 °C). To characterize the liquid handler's dispensing performance for such a large portfolio of reagents, four representative test fluids were developed by Losleben et al 31 These test liquids encompass the range of viscosity and surface tension as depicted in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast to inkjet printing, where special inks with known and optimized rheological properties are used, dispensing of biochemical liquids means handling fluids with very diverse properties. [30][31][32] This prototype system was designed to handle approximately 600 different diagnostic reagents from a leading in vitro diagnostic company. Viscosity and surface tension of the liquid formulations range from 1.03 to 16.98 mPas and 30.49 to 70.83 mN/m (at 20 °C).…”

Section: Introductionmentioning

confidence: 99%

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A Calibration-Free, Noncontact, Disposable Liquid Dispensing Cartridge Featuring an Online Process Control

et al. 2014

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We present a noncontact liquid dispenser that uses a disposable cartridge for the calibration-free dosage of diverse biochemical reagents from the nanoliter to the microliter range. The dispensing system combines the advantages of a positive displacement syringe pump (responsible for defining the aliquot's volume with high accuracy) with a highly dynamic noncontact dispenser (providing kinetic energy to detach the liquid from the tip). The disposable, noncontact dispensing cartridge system renders elaborate washing procedures of tips obsolete. A noncontact sensor monitors the dispensing process to enable an online process control. To further increase confidence and reliability for particularly critical biomedical applications, an optional closed-loop control prevents malfunctions. The dispensing performance was characterized experimentally in the range of 0.25 to 10.0 µL using liquids of different rheological properties (viscosity 1.03-16.98 mPas, surface tension 30.49-70.83 mN/m) without adjusting or calibrating the actuation parameters. The precision ranged between a coefficient of variation of 0.5% and 5.3%, and the accuracy was below ±10%. The presented technology has the potential to contribute significantly to the improvement of biochemical liquid handling for laboratory automation in terms of usability, miniaturization, cost reduction, and safety.

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Jetting Dispenser Height Effect on the Accuracy of Test Strip for Blood Glucose

et al. 2018

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Model fluids representing aqueous in-vitro diagnostic reagents for the development of dispensing systems

Cited by 4 publications

References 11 publications

Effect of filling pressure in jetting dispenser on the performance of blood glucose test strips using immersion gold-plated printed circuit board

Effect of filling pressure in jetting dispenser on the performance of blood glucose test strips using immersion gold-plated printed circuit board

A Calibration-Free, Noncontact, Disposable Liquid Dispensing Cartridge Featuring an Online Process Control

Jetting Dispenser Height Effect on the Accuracy of Test Strip for Blood Glucose

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