2000
DOI: 10.1016/s0006-3495(00)76375-2
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Model Energy Landscapes and the Force-Induced Dissociation of Ligand-Receptor Bonds

Abstract: We discuss models for the force-induced dissociation of a ligand-receptor bond, occurring in the context of cell adhesion or single molecule unbinding force measurements. We consider a bond with a structured energy landscape which is modeled by a network of force dependent transition rates between intermediate states. The behavior of a model with only one intermediate state and a model describing a molecular zipper is studied. We calculate the bond lifetime as a function of an applied force and unbinding force… Show more

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Cited by 147 publications
(121 citation statements)
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“…(iii) Assume that the model (28), (29) is applicable and deduce its model parameters µ = (λ, α) from the slope and the axis intercept of the straight line as detailed e.g. in [1,12,15,16,35]. We have applied this procedure to each of the 10000 experiments in Fig.…”
Section: B Illustration For Computer Generated Datamentioning
confidence: 99%
“…(iii) Assume that the model (28), (29) is applicable and deduce its model parameters µ = (λ, α) from the slope and the axis intercept of the straight line as detailed e.g. in [1,12,15,16,35]. We have applied this procedure to each of the 10000 experiments in Fig.…”
Section: B Illustration For Computer Generated Datamentioning
confidence: 99%
“…Let t 0 be the time at which the inner barrier disappears, defined as t 0 = E A /(rx A ), and let t max be the maximum time for the integration of the evolution equations (10) and (11). Thus, with our parameter choice, we took t max < t 0 .…”
Section: Resultsmentioning
confidence: 99%
“…In this case, a slightly modified version of eqs. (10) and (11) has to be considered to take into account the disappearing of the barrier (x A , E A ) at t = t 0 . The outcome for q(f, r) is similar to that shown in fig.…”
Section: Resultsmentioning
confidence: 99%
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“…As a result, analytical studies of forceinduced molecular transitions in such systems usually focus on the effective rate k eff ðFÞ at constant force (16,17). An expression for the quantity of relevance to force-ramp experiments-the most probable rupture force F*ðV Þ at pulling speed V-has been attempted empirically (17): the single-barrier rate kðFÞ was replaced by the multiple-barrier rate k eff ðFÞ in the single-barrier version of the expression for F*ðV Þ.…”
mentioning
confidence: 99%