Model development and experimental validation for analyzing initial transients of irradiation of tissues during thermal therapy using short pulse lasers

Ganguly, Mohit; Miller, Stephanie A.; Mitra, Kunal

doi:10.1002/lsm.22407

Cited by 21 publications

(7 citation statements)

References 38 publications

(48 reference statements)

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“…Manuchehrabadi et al [13] applied the computational Monte Carlo simulation algorithm to simulate the temperature elevation in prostatic tumor embedded in a mouse body during the treatment of laser combined with gold nanorods. In Ganguly’s study [14], finite element modeling was used to demonstrate the temperature distribution and heat affected zone of excised rat skin samples and live anesthetized mouse tissue during laser irradiation. In Paul’s study [15], finite element-based commercial software was used to simulate the subsurface thermal behavior of tissue phantom embedded with large blood vessels during plasmonic photo-thermal therapy.…”

Section: Introductionmentioning

confidence: 99%

Mathematical simulation of temperature distribution in tumor tissue and surrounding healthy tissue treated by laser combined with indocyanine green

Long

Yang

et al. 2019

Theor Biol Med Model

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Background Photothermal therapy is a local treatment method for cancer and the heat energy generated from it could destroy the tumor cells. This study is aimed to investigate the temperature distribution in tumor tissue and surrounding health tissue of tumor bearing mice applying mathematical simulation model. Tumor bearing mice treated by laser combined with or without indocyanine green. Monte Carlo method and the Pennes bio-heat equation were used to calculate the light distribution and heat energy. COMSOL Multiphysic was adopted to construct three dimensional temperature distribution model. Results This study revealed that the data calculated by simulation model is in good agreement with the surface temperature monitored by infrared thermometer. Effected by the optical parameters and boundary conditions of tissue, the highest temperature of tissue treated by laser combined with indocyanine green was about 65 °C which located in tumor tissue and the highest temperature of tissue treated by laser was about 43 °C which located under the tumor tissue. The temperature difference was about 20 °C. Temperature distribution in tissue was not uniform. The temperature difference in different parts of tumor tissue raised up to 15 °C. The temperature of tumor tissue treated by laser combined with indocyanine green was about 20 °C higher than that of the surrounding healthy tissue. Conclusions Reasonably good matching between the calculated temperature and the measured temperature was achieved, thus demonstrated great utility of our modeling method and approaches for deepening understand in the temperature distribution in tumor tissue and surrounding healthy tissue during the laser combined with photosensitizer. The simulation model could provide guidance and reference function for the effect of photothermal therapy. Electronic supplementary material The online version of this article (10.1186/s12976-019-0107-3) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Mathematical simulation of temperature distribution in tumor tissue and surrounding healthy tissue treated by laser combined with indocyanine green

Long

Yang

et al. 2019

Theor Biol Med Model

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“…First, energy loss is associated to blood flow (32). The temperature distribution in vivo is usually non-uniform, due to tissue cooling by blood flow (33). The aforementioned phenomenon remains a challenge to avoid.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of temperature changes in photothermal therapy induced by combined application of indocyanine green and laser

Long

Zhou

et al. 2019

Oncol Lett

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Photothermal therapy, a type of laser application, has the ability to eradicate tumor cells by a local thermal effect and elicit a tumor specific immune response. Indocyanine green (ICG), a photosensitizer, can effectively elevate the local temperature by absorbing energy from the laser. The present study aimed to investigate the characteristics of temperature changes during photothermal therapy with an infrared thermometer in an ICG solution and in tumor-bearing mice treated with a combination of laser and ICG. Additionally, the present study observed the morphological changes of tumor tissue by hematoxylin-eosin staining following photothermal therapy. In the solution experiment, when the laser power density was 1 W/cm 2 and the concentration of ICG was 0 or 0.0187 mg/ml, the temperature of the water was elevated by 3 and 28˚C, respectively. In the tumor-bearing mice experiment, when the laser power density was 1 W/cm 2 and the concentration of ICG was 0 and 0.1 mg/ml, the temperature of the tumor-bearing mice was elevated by 6.9 and 28.5˚C, respectively. With an increase in laser power density, including 0.6, 0.8 and 1.0 W/cm 2 , the temperature was 23.3, 26.7 and 28.5˚C, respectively. Pathological tissue sections demonstrated that a large number of tumor cells experienced necrosis, and the envelope of the tumor was destroyed. Numerous inflammatory cells, in particular lymphocytes, infiltrated into the tumor tissue following tumor tissue treatment with a combination of laser and ICG. These results indicated that a combination treatment with laser and ICG may significantly increase the temperature of the water solutions and in the tumor-bearing mice. The concentration of ICG and laser power density contributed to the temperature elevation, in particular to the concentration of ICG.

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“…As computational models are a powerful, fast, and cheap tool to attain useful information on the electrical‐thermal processes associated with energy‐based therapies , this method was used to simulate the electric, thermal and tissue damage response of a two‐dimensional model of cardiac tissue subjected to RF ablation.…”

Section: Methodsmentioning

confidence: 99%

Relation between denaturation time measured by optical coherence reflectometry and thermal lesion depth during radiofrequency cardiac ablation: Feasibility numerical study

González-Suárez¹,

Herranz²,

Berjano

et al. 2017

Lasers Surg Med

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Model development and experimental validation for analyzing initial transients of irradiation of tissues during thermal therapy using short pulse lasers

Cited by 21 publications

References 38 publications

Mathematical simulation of temperature distribution in tumor tissue and surrounding healthy tissue treated by laser combined with indocyanine green

Mathematical simulation of temperature distribution in tumor tissue and surrounding healthy tissue treated by laser combined with indocyanine green

Characteristics of temperature changes in photothermal therapy induced by combined application of indocyanine green and laser

Relation between denaturation time measured by optical coherence reflectometry and thermal lesion depth during radiofrequency cardiac ablation: Feasibility numerical study

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