Model-based Patient Matching for in-parallel Multiplexing Mechanical Ventilation Support

Wong, Jin Wai; Chiew, Yeong Shiong; Desaive, Thomas; Chase, J. Geoffrey

doi:10.1016/j.ifacol.2021.10.242

Cited by 2 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to this, we must also consider the hypothetical limitations of multiplexing. For example, while it may be theoretically possible to multiplex three or more patients on one ventilator using computer modeling [ 49 , 50 ], or lung models [ 23 , 51 ], this may not be feasible nor safe in practice due to circuit complexity resulting in potential confusion and cross contamination, overburdening of the ventilator’s capacity, and other unknowns. Challenges in continuous monitoring must be addressed prior to human studies to ensure patient safety.…”

Section: Discussionmentioning

confidence: 99%

Translational design for limited resource settings as demonstrated by Vent-Lock, a 3D-printed ventilator multiplexer

Xun¹,

Shallal

Unger

et al. 2022

3D Print Med

View full text Add to dashboard Cite

Background Mechanical ventilators are essential to patients who become critically ill with acute respiratory distress syndrome (ARDS), and shortages have been reported due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods We utilized 3D printing (3DP) technology to rapidly prototype and test critical components for a novel ventilator multiplexer system, Vent-Lock, to split one ventilator or anesthesia gas machine between two patients. FloRest, a novel 3DP flow restrictor, provides clinicians control of tidal volumes and positive end expiratory pressure (PEEP), using the 3DP manometer adaptor to monitor pressures. We tested the ventilator splitter circuit in simulation centers between artificial lungs and used an anesthesia gas machine to successfully ventilate two swine. Results As one of the first studies to demonstrate splitting one anesthesia gas machine between two swine, we present proof-of-concept of a de novo, closed, multiplexing system, with flow restriction for potential individualized patient therapy. Conclusions While possible, due to the complexity, need for experienced operators, and associated risks, ventilator multiplexing should only be reserved for urgent situations with no other alternatives. Our report underscores the initial design and engineering considerations required for rapid medical device prototyping via 3D printing in limited resource environments, including considerations for design, material selection, production, and distribution. We note that optimization of engineering may minimize 3D printing production risks but may not address the inherent risks of the device or change its indications. Thus, our case report provides insights to inform future rapid prototyping of medical devices.

show abstract