Model and Method for Optimal Sizing of Serial Microfiltration Systems

Giglia, Sal; Straeffer, Greg

doi:10.12665/j123.giglia

Search citation statements

Order By: Relevance

Paper Sections

Select...

Current Upscaling Procedures For Dead-end Microfiltration1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The initial flux decreases with increasing filter area due to occurrence of additional flow resistances connected with device construction, tubing and fittings [32]. Other reviews about experimental procedure, theoretical approaches, and aspects to consider for conducting microfiltration upscaling studies are given in the literature [31,32,34,41].…”

Section: Current Upscaling Procedures For Dead-end Microfiltrationmentioning

confidence: 99%

Scale‐up of Microfiltration Processes

Haindl

Stark

Dippel

et al. 2020

Chemie Ingenieur Technik

View full text Add to dashboard Cite

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Supporting Information available onlineA flow rate and resistance-based approach for upscaling of microfiltration processes from lab scale to process scale is presented, in correlation with biopharmaceutical processes. Basic element is the modeling of filtration curves using a resistance-in-series model based on the Darcy equation. The influences of the filtration setup and the fouling layer are described as additional resistances that change in course of filtration. The necessary parameters, such as setup resistances and filtration areas, are determined by water flow rate measurements. The model is validated by filtration of a particulate test solution. The presented approach can be used for constant flow and constant pressure driven filtration processes.

show abstract