Mode of Mast Cell Degranulation

Moriyasu, Shojiro

doi:10.2336/nishinihonhifu.33.223

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Systemic Mastocytosis Uftrastructure 4471

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1975

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“…shaped granules in the neoplastic mast cells of mouse and dog mastocytoma. We do not know if the semi lunar granules in liver mast cells have a special significance, but it seems that they are not related to tbe process of mast cell degranulation, since experimental work in this direction did not reveal such granules (6,8).…”

Section: Systemic Mastocytosis Uftrastructure 447mentioning

confidence: 94%

Ultrastructural features of mast cells in systemic mastocytosis

Naveh¹,

Ludatscher²,

Gellei³

et al. 1975

Acta Derm Venereol

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A 3-year-old boy with systemic mastocytosis has been observed since the age of 4 months when he was first diagnosed as suffering from urticaria pigmentosa. Involvement of skin, liver, spleen and bones was observed. The electron microscopy of skin and liver revealed varied alterations in the morphology of mast cells. The most important findings were irregularly-shaped cells and unusual long and interdigitated cytoplasmic villi, with consequent aggregation of mast cells which was more prominent in the dermis. Proliferation and accumulation of mitochondria in one part of the cell and deeply indented nuclei were frequent. The problem, whether the morphological changes encountered--especially the complex interdigitation of villi--should be interpreted as a sign of expected neoplastic development, is discussed.

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Section: Systemic Mastocytosis Uftrastructure 447mentioning

confidence: 94%