Mode of invasion and lymph node metastasis in squamous cell carcinoma of the oral cavity

Abstract

The relationship between the mode of tumor invasion in the tumor-host borderline and the frequency of regional lymph node metastasis was investigated in squamous cell carcinoma of the oral cavity. Cases with grades 1-3 mode of invasion classified by modified Jacobsson criteria showed a low frequency of metastasis (10/72, 13.9%), while those cases with grade 4 mode of invasion, which consisted of grade 4C (cord-like type) and grade 4D (diffuse type) showed a high frequency of metastasis (4C:11/18,61.1%; 4D :9/12,75.0%; total 20/30,66.7%). Moreover, the number of metastatic nodes in each case of mode of invasion ranged from 1 to 3 in grades 1-3, from 1 to 5 in grade 4C, and from 1 to 7 in grade 4D . The presence of metastasis indicated a poorer prognosis than did the absence of the mode of invasion in each grade, especially in grades 4C and 4D .

Expression of E-cadherin, α-catenin, and β-catenin in the process of lymph node metastasis in oral squamous cell carcinoma

“…However, the features of the metastatic lesion may be independent of those of the primary lesion and may be mainly influenced by circumustances unique to the metastatic lesion itself. Mode of carcinoma invasion evaluated from the biopsied specimens has already been reported to be related to regional metastasis (Yamamoto et al, 1984), which is consistent with the result of the current study. Tumour invasion is also related to intercellular adhesion and there were also correlations between the mode of carcinoma invasion and the expressions of E-cadherin, acatenin and b-catenin.…”

Pain may predict poor prognosis in patients with oral squamous cell carcinoma

“…15 Since significant correlations have been reported between the histological mode of invasion and patient prognosis, 15,16,[19][20][21] we hypothesized that pain in patients with oral cancer may be significantly correlated with patient poor prognosis.…”

Downregulation of Wnt4 and upregulation of Wnt5a expression by epithelialmesenchymal transition in human squamous carcinoma cells

“…The Yamamoto-Kohama (Y-K) mode of invasion 49,50) has been useful in predicting the prognosis of patients with an oral SCC. A significantly poor prognosis has been reported in the patients with SCC showing Y-K grade 4D (diffuse type) mode of invasion, the most invasive type in the Y-K classification, which is seen in about 10% of oral SCCs.…”