Mode of Delivery Is Associated With Asthma and Allergy Occurrences in Children

Salam, Muhammad T.; Margolis, Helene G.; McConnell, Rob; McGregor, James A.; Avol, Edward L.; Gilliland, Frank D.

doi:10.1016/j.annepidem.2005.06.054

Cited by 96 publications

(88 citation statements)

References 35 publications

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“…Unlike these results, higher prevalence of asthma was found among children who had been breastfeed [43] and also reported that breastfeeding does not protect children against atopy and asthma and may even increase the risk [44]. Likewise, we observed caesarean mode of delivery was found significantly associated with asthma risk, as reported earlier also [45,46]. Unlike these studies, some studies have reported that mode of delivery is not associated with subsequent risk of developing childhood asthma or wheezing episodes [47,48].…”

Section: Discussioncontrasting

confidence: 56%

CFTR Gene Mutations and Asthma in Indian Children: A Case–Control Study

Dixit¹,

Awasthi²,

Maurya³

et al. 2013

Ind J Clin Biochem

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Cystic Fibrosis Trans membrane conductance regulator (CFTR) gene is an asthma susceptibility gene. In the present study we investigated the possible association of CFTR gene mutations in Indian asthmatic children as compared to controls. The study included 250 asthmatics and 250 age and sex matched controls. Case to control ratio for sample size was 1:1. Genotyping was performed for 24 CFTR gene mutations by ARMS-PCR and PCR-RFLP method. Among 24 CFTR gene mutations, heterozygous allele of R553X mutation was found in 4 (1.6 %) asthmatic cases and 2 (0.8 %) controls. Value of FVC and FEV1/ FVC ratio were significantly lower in heterozygous individuals (p value \0.05). No significant difference was observed in the genotype and allele frequency of R553X mutation (OR = 1.339, 95 % CI = 0.755-2.374, p value = 0.685). Furthermore, all wild type homozygous alleles were observed in remaining 23 CFTR gene mutations. Our data concludes that R553X mutation was not significantly associated in Indian asthmatic children.

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Section: Discussioncontrasting

confidence: 56%

CFTR Gene Mutations and Asthma in Indian Children: A Case–Control Study

Dixit¹,

Awasthi²,

Maurya³

et al. 2013

Ind J Clin Biochem

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“…Previous studies (11)(12)(13)(14)(15)(16)(17)(18) of this issue have produced inconsistent results. There are a number of methodologic issues that should be evaluated when considering the association between asthma and cesarean birth: criteria for selection of the study population (i.e., exclusion or inclusion of premature or low birth weight infants), controlling for factors associated with cesarean delivery (i.e., prematurity, maternal obesity, maternal asthma, and social class), variations in the ratio of emergency and elective cesarean section in different regions, as well as duration of follow-up.…”

Section: Discussionmentioning

confidence: 95%

“…Fetal development seems therefore to represent a critical time of pulmonary vulnerability with respect to smoking exposure. More recently, some studies have also investigated the relationships between exposure to maternal infections in pregnancy (6-8), maternal obstetric conditions (hyperemesis, hypertension, and preeclampsia) (9-11), uterine factors (antepartum hemorrhage, preterm contractions, placental insufficiency, and uterine growth restriction) (9-11), malposition or malpresentation of the fetus (11), mode of delivery (11)(12)(13)(14)(15)(16)(17)(18), and the development of asthma among offspring. However, the findings of these studies have been inconsistent.…”

mentioning

confidence: 99%

Maternal Complications and Procedures in Pregnancy and at Birth and Wheezing Phenotypes in Children

Rusconi

Galassi

Forastiére

et al. 2007

Am J Respir Crit Care Med

138

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Rationale: There is increasing interest in the potential influence of fetal and early life conditions on childhood wheezing. Objectives: To investigate the associations between maternal complications and procedures in pregnancy and at birth and the risk of various wheezing phenotypes in young children. Methods: We studied 15,609 children, aged 6-7 yr, enrolled in a population-based study. Standardized questionnaires were completed by the children's mothers. AT A GLANCE COMMENTARY Scientific Knowledge on the SubjectMaternal smoking in pregnancy influences lung development and is associated with wheezing in childhood; other prenatal and perinatal factors (maternal infections, obstetric conditions) have been inconclusively associated with wheezing among offspring. What This Study Adds to the FieldAn association was found between maternal hypertension, diabetes, and urinary tract infections during pregnancy and exposure to antibiotics at delivery with wheezing disorders, in particular wheezing of early onset.(1). The most studied in utero environmental influence on lung development is maternal smoking in pregnancy, which has been shown to be associated not only with wheezing in childhood (2-5) but also with a dose-related reduction in lung function in the newborn period. Fetal development seems therefore to represent a critical time of pulmonary vulnerability with respect to smoking exposure. More recently, some studies have also investigated the relationships between exposure to maternal infections in pregnancy (6-8), maternal obstetric conditions (hyperemesis, hypertension, and preeclampsia) (9-11), uterine factors (antepartum hemorrhage, preterm contractions, placental insufficiency, and uterine growth restriction) (9-11), malposition or malpresentation of the fetus (11), mode of delivery (11)(12)(13)(14)(15)(16)(17)(18), and the development of asthma among offspring. However, the findings of these studies have been inconsistent.In a report published in 1999 (19), we found associations between a number of pre-, peri-, and early postnatal factors and different wheezing phenotypes in a large multicenter crosssectional population-based study, the SIDRIA (Italian Studies of Respiratory Disorders in Childhood and the Environment) phase 1 study, an extension of the International Study on Asthma and Allergies in Childhood (ISAAC) phase 1 study (20). The enrolled children were categorized, on the basis of criteria derived from Martinez and coworkers (21), as transient early wheezers (children with wheezing in the first 2 yr of life but not at school age), persistent wheezers (children who continued to wheeze at school age), late-onset wheezers (children who did not wheeze in the first years of life but who wheezed when 6-7 yr

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“…With this high rate of Caesarean section, the cost of maternity care has also markedly increased [46]. Second, Caesarean sections that are performed for non-medical reasons, may have adverse side effects, such as: increased risk of stillbirth in the next pregnancy, reduced fertility, and allergy or asthma in the child [47][48][49][50][51][52].…”

Section: Discussionmentioning

confidence: 99%

The impact of the mass media on obstetricians’ behavior in Norway

2017

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Little is known about how physicians and hospitals respond to the risk of being negatively exposed in the mass media. We assume that newspapers will cover events more closely in the areas where they have most of their circulation. Within such areas the likelihood of negative publicity increases. The research question is whether obstetricians respond to negative newspaper coverage by choosing the least risky method of delivery, i.e. Caesarean section. This was tested on a large set of data from the Medical Birth Registry of Norway for the period 2000-2011. The Registry contains detailed medical information about all deliveries, for both the mother and the infant. This set of data was merged with a set of data that contained information about newspaper coverage for the municipalities in which all hospitals were located. Altogether, more than 620 000 deliveries in 46 municipalities were included in the study. The data were analyzed using a hospital 3 fixed effects regression. The main result was that newspaper coverage had a significant positive effect on the probability of having a Caesarean section. Several supplementary analyses supported the main finding. Altogether, our results indicate that obstetricians are sensitive to the risk of being exposed in the mass media. This is likely to be because obstetricians care about their reputation.

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Mode of Delivery Is Associated With Asthma and Allergy Occurrences in Children

Cited by 96 publications

References 35 publications

CFTR Gene Mutations and Asthma in Indian Children: A Case–Control Study

CFTR Gene Mutations and Asthma in Indian Children: A Case–Control Study

Maternal Complications and Procedures in Pregnancy and at Birth and Wheezing Phenotypes in Children

The impact of the mass media on obstetricians’ behavior in Norway

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