Mode of Delivery and Risk of Respiratory Diseases in Newborns

Levine, Elliot M.; Ghai, Vivek; Barton, John; Strom, Charles M.

doi:10.1097/00006250-200106000-00035

Cited by 100 publications

(24 citation statements)

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“…Several studies have shown a difference in neonatal outcomes for labored versus unlabored cesarean delivery. [6][7][8][9] The dilemma is predicting who among a group of women planning for a vaginal delivery will actually have a vaginal delivery. Also, many women who plan to have a vaginal delivery, especially first-time mothers, actually deliver by cesarean after labor.…”

Section: Introductionmentioning

confidence: 99%

Neonatal outcomes associated with planned vaginal versus planned primary cesarean delivery

Geller

Jannelli

et al. 2009

J Perinatol

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Objective: To determine whether planned route of delivery leads to differences in neonatal morbidity.Study Design: Analysis was based on planned route of delivery, not actual route of delivery. A total of 4048 subjects were divided into two groups: planned vaginal delivery and planned cesarean delivery. Primary outcomes were neonatal intensive care unit (NICU) admission, respiratory morbidity and neurologic morbidity.Result: There were 3868 planned vaginal and 180 planned cesarean deliveries. Planned vaginal delivery had decreased NICU admission (P<0.0001), oxygen resuscitation (P ¼ 0.001) and jaundice (P<0.0001) but increased meconium passage (P<0.0001) and 1 min Apgar p5 (P ¼ 0.02). After multivariable regression, NICU admission remained lower and meconium passage remained higher in the planned vaginal group.Conclusion: Planned vaginal delivery led to more meconium passage and low 1 min Apgar but less NICU admissions, oxygen resuscitation and jaundice. Multicenter trials are needed to assess rare but serious outcomes based on planned route of delivery.

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Section: Introductionmentioning

confidence: 99%

Neonatal outcomes associated with planned vaginal versus planned primary cesarean delivery

Geller

Jannelli

et al. 2009

J Perinatol

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“…According to Levine, et al (2001), the incidence of pulmonary hypertension in neonates is about five times greater in individuals born by cesarean compared to the traditional delivery procedure [18]. Several authors have investigated the consequences of a cesarean delivery, such as the occurrence of uterine rupture [19].…”

Section: Pancreatitis Symptomsmentioning

confidence: 99%

Parenteral Nutrition in the Newborn: Associated Disorders and Nutritional Aspects

Ac¹,

Freitas²

2016

Journal of Nutrition and Health sciences

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“…Moreover, this study did not replicate the previously established associations between PPHN and postmaturity, cesarean delivery, meconium staining of the amniotic fluid, male gender of the infant, or African American ethnicity. [10][11][12][13]37,38 One recent study of the association between selective serotonin reuptake inhibitors and PPHN risk from 5 Nordic countries observed no association between NSAID use and PPHN. 39 The main limitation of the current study is the reliance on maternal recall for information about exposure status.…”

Section: Figurementioning

confidence: 99%

Nonsteroidal Antiinflammatory Drugs in Late Pregnancy and Persistent Pulmonary Hypertension of the Newborn

2012

PEDIATRICS

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WHAT'S KNOWN ON THIS SUBJECT: Knowledge is limited regarding the epidemiology of persistent pulmonary hypertension of the newborn (PPHN). Previous work has implicated a host of perinatal risk factors and a few antenatal antecedents of PPHN, including maternal consumption during pregnancy of nonsteroidal antiinflammatory medications. WHAT THIS STUDY ADDS:In contrast to results of previous studies, we found no association between PPHN and maternal consumption during late pregnancy of nonsteroidal antiinflammatory drugs in general or ibuprofen in particular. abstract OBJECTIVE: Persistent pulmonary hypertension of the newborn (PPHN) is a clinical syndrome of late-preterm and full-term infants associated with failure of the normal fetal-to-neonatal circulatory transition. This study was designed to test the hypothesis that risk for PPHN is increased after antenatal exposure to nonsteroidal antiinflammatory drugs (NSAIDs), with particular emphasis on late gestational exposures. METHODS:Between 1998 and 2003, we interviewed 377 women whose infants had PPHN and 836 control mothers of infants matched to cases by hospital and birth date. Interviews captured information on prescription and over-the-counter medication use in pregnancy as well as a variety of potential confounding factors. Crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for third-trimester maternal NSAID use were estimated by using multivariate conditional logistic regression. RESULTS:During the third trimester of gestation, 33 infants (8.8%) with PPHN were exposed to any NSAID compared with 80 (9.6%) controls (OR 0.8; 95% CI 0.5-1.3). We observed an elevated OR for PPHN risk among infants whose mothers consumed aspirin during the third-trimester; however, the lower 95% CI included the null. Neither nonaspirin NSAIDs at any time during pregnancy nor ibuprofen use during the third trimester was associated with an elevated risk of PPHN. Similarly, no association was observed between a mother' s third-trimester acetaminophen use and the occurrence of PPHN in her newborn.CONCLUSIONS: This large multicenter epidemiologic study of PPHN risk revealed no evidence to support the hypothesis that maternal consumption during pregnancy of NSAIDs overall or ibuprofen in particular is associated with PPHN risk. All authors made substantive intellectual contributions to this study; each has contributed sufficiently in the work to take public responsibility for appropriate portions of the content; and each has seen and approved the final submission version of the manuscript.www.pediatrics.org/cgi

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Mode of Delivery and Risk of Respiratory Diseases in Newborns

Cited by 100 publications

References 0 publications

Neonatal outcomes associated with planned vaginal versus planned primary cesarean delivery

Neonatal outcomes associated with planned vaginal versus planned primary cesarean delivery

Parenteral Nutrition in the Newborn: Associated Disorders and Nutritional Aspects

Nonsteroidal Antiinflammatory Drugs in Late Pregnancy and Persistent Pulmonary Hypertension of the Newborn

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