Mode of Death After Acute Heart Failure Hospitalization　– A Clue to Possible Mechanisms –

Parikh, Kishan S.; Felker, G. Michael; Metra, Marco

doi:10.1253/circj.cj-15-1006

Cited by 13 publications

(5 citation statements)

References 82 publications

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“…Our data suggested that the PVS might be useful for the prediction of the mode of death in patients admitted with ADHF. Because there is very little data available on the mode of death in ADHF patients, 35 we cannot fully explain why a lower ∆PVS was associated with a lower risk of PFD but not with a lower risk of SCD. Moreover, our data showed that the PVS was also useful for the prediction of cardiac death, non-cardiac death, and unplanned hospitalization for worsening HF, although the ∆PVS had no association with non-cardiac death or unplanned hospitalization for worsening HF.…”

Section: Discussionmentioning

confidence: 91%

Prognostic Value of Calculated Plasma Volume Status in Patients Admitted for Acute Decompensated Heart Failure　― A Prospective Comparative Study With Other Indices of Plasma Volume ―

et al. 2019

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Background: Congestion is one of the main predictors of poor outcome in patients with heart failure (HF); thus, a simple tool to evaluate plasma volume (PV), which can be used for risk stratification of HF patients, is necessary. We sought to compare the prognostic values of commonly used formulas for the estimation of PV and relative PV status (PVS) in patients admitted with acute decompensated HF (ADHF). Methods and Results: We analyzed 384 consecutive ADHF patients who survived to discharge. The PV was calculated by 3 commonly used formulas (Strauss, Kaplan, and Hakim), and the relative PVS was calculated using the Hakim formula at both admission and discharge. The primary endpoint was a composite of all-cause mortality and hospitalization for worsening HF. The secondary endpoints were pump failure death (PFD) and sudden cardiac death (SCD). During a median follow-up of 743 days, 175 patients reached the primary endpoint, 28 patients had PFD, and 20 patients had SCD. Multivariate Cox analysis revealed that among the PV indices, only the PVS values at admission and discharge were independent predictors of the primary endpoint. In addition, the PVS values at admission and discharge were independent predictors of PFD and SCD in the multivariate analysis. Conclusions: Among the indices of PV, the calculated PVS may be the most useful for predicting prognosis in ADHF patients.

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Section: Discussionmentioning

confidence: 91%

Prognostic Value of Calculated Plasma Volume Status in Patients Admitted for Acute Decompensated Heart Failure　― A Prospective Comparative Study With Other Indices of Plasma Volume ―

et al. 2019

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“…In comparison to patients with chronic HF, patients with AHF have higher short-term event rates and a higher proportion of HF deaths versus other causes of death (9). In RELAX-AHF-2, patients had a 180-day mortality of 11.5% after AHF hospitalization, with a large proportion of deaths due to HF (38%).…”

Section: Resultsmentioning

confidence: 99%

Cause of Death in Patients With Acute Heart Failure

Loungani¹,

Teerlink²,

Metra³

et al. 2020

JACC: Heart Failure

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OBJECTIVES This study sought to better understand the discrepant results of 2 trials of serelaxin on acute heart failure (AHF) and short-term mortality after AHF by analyzing causes of death of patients in the RELAX-AHF-2 (Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in AHF-2) trial.BACKGROUND Patients with AHF continue to suffer significant short-term mortality, but limited systematic analyses of causes of death in this patient population are available.METHODS Adjudicated cause of death of patients in RELAX-AHF-2, a randomized, double-blind, placebo-controlled trial of serelaxin in patients with AHF across the spectrum of ejection fraction (EF), was analyzed.RESULTS By 180 days of follow-up, 11.5% of patients in RELAX-AHF-2 died, primarily due to heart failure (HF) (38% of all deaths). Unlike RELAX-AHF, there was no apparent effect of treatment with serelaxin on any category of cause of death. Older patients ($75 years) had higher rates of mortality (14.2% vs. 8.8%) and noncardiovascular (CV) death (27% vs. 19%) compared to younger patients. Patients with preserved EF ($50%) had lower rates of HF-related mortality (30% vs. 40%) but higher non-CV mortality (36% vs. 20%) compared to patients with reduced EF.CONCLUSIONS Despite previous data suggesting benefit of serelaxin in AHF, treatment with serelaxin was not found to improve overall mortality or have an effect on any category of cause of death in RELAX-AHF-2. Careful adjudication of events in the serelaxin trials showed that older patients and those with preserved EF had fewer deaths from HF or sudden death and more deaths from other CV causes and from noncardiac causes.

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“…Acute decompensated heart failure (ADHF) is a common reason for frequent hospital admission and has been associated with increased short-term mortality and poor long-term prognosis [1][2][3][4]. Increased early mortality in ADHF has been associated with altered cardiovascular physiology, such as hypotension, impaired renal function, impaired left ventricular function, and abnormal biomarkers [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Association between elevated blood glucose level on admission and long-term mortality in patients with acute decompensated heart failure

Kattel

Kasai

Matsumoto

et al. 2017

Journal of Cardiology

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Mode of Death After Acute Heart Failure Hospitalization　– A Clue to Possible Mechanisms –

Cited by 13 publications

References 82 publications

Prognostic Value of Calculated Plasma Volume Status in Patients Admitted for Acute Decompensated Heart Failure　― A Prospective Comparative Study With Other Indices of Plasma Volume ―

Prognostic Value of Calculated Plasma Volume Status in Patients Admitted for Acute Decompensated Heart Failure　― A Prospective Comparative Study With Other Indices of Plasma Volume ―

Cause of Death in Patients With Acute Heart Failure

Association between elevated blood glucose level on admission and long-term mortality in patients with acute decompensated heart failure

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Mode of Death After Acute Heart Failure Hospitalization – A Clue to Possible Mechanisms –

Cited by 13 publications

References 82 publications

Prognostic Value of Calculated Plasma Volume Status in Patients Admitted for Acute Decompensated Heart Failure ― A Prospective Comparative Study With Other Indices of Plasma Volume ―

Prognostic Value of Calculated Plasma Volume Status in Patients Admitted for Acute Decompensated Heart Failure ― A Prospective Comparative Study With Other Indices of Plasma Volume ―

Cause of Death in Patients With Acute Heart Failure

Association between elevated blood glucose level on admission and long-term mortality in patients with acute decompensated heart failure

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Mode of Death After Acute Heart Failure Hospitalization　– A Clue to Possible Mechanisms –

Prognostic Value of Calculated Plasma Volume Status in Patients Admitted for Acute Decompensated Heart Failure　― A Prospective Comparative Study With Other Indices of Plasma Volume ―

Prognostic Value of Calculated Plasma Volume Status in Patients Admitted for Acute Decompensated Heart Failure　― A Prospective Comparative Study With Other Indices of Plasma Volume ―