J. Neurosci. Res. volume 86, issue 1, P93-107 2007 DOI: 10.1002/jnr.21468 View full text
H. Ulrich, G. Akk, A.A. Nery, C.A. Trujillo, A.D. Rodriguez, V.A. Eterović

Abstract: The mechanism of eupalmerin acetate (EUAC) actions on the embryonic muscle nicotinic acetylcholine receptor (nAChR) in BC3H-1 cells was studied by using whole-cell and single-channel patch-clamp current measurements. With whole-cell currents, EUAC did not act as an agonist on this receptor. Coapplication of 30 microM EUAC with 50 microM, 100 microM, or 500 microM carbamoylcholine (CCh) reversibly inhibited the current amplitude, whereas, with 20 microM CCh, current was increased above control values in the pre…

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