Mode of antibacterial action of retrochalcones from Glycyrrhiza inflata

Antimycobacterial Activity Some Different Lamiaceae Plant Extracts Containing Flavonoids and Other Phenolic Compounds

“…Until 2004, it was suggested Lamb, 2005, 2011) that their antibacterial efficacy was dependent upon cytoplasmic membrane damage by perforation (Ikigai et al, 1993), inhibition of nucleic acid synthesis (Mori et al, 1987) and disruption of energy metabolism due to NADH-cytochrome c reductase inhibition (Haraguchi et al, 1998). Currently, some other supporting mechanisms have emerged to indicate the role of flavonoids in antibacterial activity; these mechanisms include damage to the cytoplasmic membrane by generating hydrogen peroxide (Tamba et al, 2007;Kusuda et al, 2006;Sirk et al, 2008), inhibition of nucleic acid synthesis (Gradisar et al, 2007;Wang et al, 2010) and inhibition of ATP synthase (Chinnam et al, 2010).…”

Cytotoxic Allyl Retrochalcone from the Roots of Glycyrrhiza inflata

“…3,4) Until now five retrochalcones, licochalcones A-D and echinatin, have been isolated and characterized from the roots of G. inflata. 2,3) Licochalcones A-D were shown to have various biological properties, e.g., antitumor, [5][6][7][8] antiparasitic, 9) antileishmanial, 10) antibacterial 11) activities. They also displayed antioxidative and superoxide scavenging effects.…”

Concise review: Medicinal plants are effective against leishmaniasis

“…Licorice is used to treat bloating, respiratory infections, peptic ulcers and gastritis. It is also used as antitussive, anti-hepatitis, and anti-tumor agent (Baba and Shigeta, 1993;Lentihet and Nygren, 1997;Sato et al, 1996;Li et al, 2011;Haraguchi et al, 1998;Csuk et al, 2010;Fukai et al, 2002). The major component of licorice is glycerisic acid (Alan Teck et al, 2007;Mehravar, 1991;Marzi et al, 1993).…”