Mode of action of α-adrenoceptor antagonists in the treatment of lower urinary tract symptoms

Effects of the 5α-reductase Inhibitor Dutasteride on Rat Prostate α1A-adrenergic Receptor and Its Mediated Contractility

“…2 It is generally accepted that norepinephrine-mediated contractions in the prostate and urethral smooth muscles contribute to the dynamic component of the outflow obstruction found in patients with BPH. 3 Contractile responses to norepinephrine in the human prostate are mediated mainly by a1-adrenoceptors. Three major subtypes of a1-adrenoceptors-a 1A , a 1B , and a 1D -have been identified in the prostate, among which the a 1A subtype has been considered to be the dominant receptor subtype controlling BPH; the a 1A subtype is thus an important therapeutic target for the treatment of BPH.…”

Noradrenaline regulates substance P release from rat dorsal root ganglion neurons in vitro

“…α1-adrenoreceptors mediate depolarization in cultured rat DRG neurons [22] . α1-adrenoreceptor agonists have been reported to increase and antagonists to reduce neurogenic inflammatory responses mediated by CAPsensitive sensory neurons [30,31] . The elevation of CAP- In conclusion, NA, by acting on α1-but not α2-adrenoreceptors, increases CAP-evoked SP release from DRG neurons, indicating that it may be one of the pronociceptive noradrenergic mechanisms in the periphery.…”

Bioequivalence of the pharmacokinetics between two formulations of 0.2 mg tamsulosin hydrochloride in healthy subjects

“…[5] α 1 -adrenoceptor antagonists relax prostatic and urethral smooth muscle and have beneficial effect on LUTS in patients with benign prostatic hyperplasia. [6] Tamsulosin relieves LUTS not only by blocking α 1A -adrenoceptors in the prostate but also by blocking α 1A -and α 1D -adrenoceptors in the bladder, which inhibit detrusor muscle contractions. Blocking these adrenoceptors causes relaxation of bladder neck and prostate smooth muscle, resulting in improved urine flow rate and reduced LUTS.…”