Mode of action of the plant-derived silphinenes on insect and mammalian GABAA receptor/chloride channel complex

Bloomquist, Jeffrey R.; Boina, Dhana Raj; Chow, Ella; Carlier, Paul R.; Reina, Matı́as; González-Coloma⊥, Azucena

doi:10.1016/j.pestbp.2007.12.002

Cited by 47 publications

(24 citation statements)

References 19 publications

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“…This study was supported by the molecular similarities between the silphinene antifeedant and the GABA antagonist picrotoxinin, and by silphinene activity on mammalian and insect CNS preparations (Bloomquist 2001(Bloomquist , 2003Bloomquist et al 2008;González-Coloma et al 2002a;Mullin et al 1997). Furthermore, betulinic acid (5) binds angiotensine I and muscarinic receptors (Zhu et al 1996), while triterpene acids such as oleanolic acid (9) and b-glycyrrhetinic acid are angiotensin blockers (Caballero-George et al 2004).…”

Section: Antifeedant Effectsmentioning

confidence: 85%

Triterpene-based plant defenses

et al. 2010

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Pentacyclic triterpenes are abundant in the plant kingdom and have a wide array of pharmacological activities. They also have insect antifeedant effects and therefore apparently play a role in plant defense. In this paper, we describe the insecticidal activity of pentacyclic triterpenes of plant origin from different chemical classes on several insect pests (Spodoptera littoralis, Leptinotarsa decemlineata and Myzus persicae), their phytotoxic properties and their selective cytotoxic effects on insect-derived Sf9 and mammalian CHO cells. We also discuss the role they play in plant defense based on these activities.

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Section: Antifeedant Effectsmentioning

confidence: 85%

Triterpene-based plant defenses

et al. 2010

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“…It has been suggested that thymol potentiates GABA A receptors through an unidentified binding site (Priestley et al, 2003). The silphinenes antagonize the action of GABA on insect neurons (Bloomquist et al, 2008;Rattan, 2010).…”

Section: Family Compoundsmentioning

confidence: 99%

Essential oils for the development of eco-friendly mosquito larvicides: A review

Pavela

2015

Industrial Crops and Products

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“…Se ha demostrado que el timol, por ejemplo, interactúa con estos receptores en un sitio de unión aun no identificado (148,149). Algunos sesquiterpenos tricíclicos han resultado ser potentes inhibidores de estos receptores (150). Asimismo, la tujona, un monoterpenoide bicíclico, se ha clasificado como un insecticida neurotóxico que también actúa sobre estos receptores (151).…”

Section: Mecanismo De Acciónunclassified

Essential oils and their components as an alternative in the control of mosquito vectors of disease

et al. 2017

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: diseño del trabajo, revisión sistematica de la actividad biológica de los aceites esenciales y revisión del manuscrito Benjamín Nogueda-Torres: diseño del trabajo, revisión sistemática de la actividad de los componentes Alejandro D. Camacho: revisión sistematica de la actividad biológica de los aceites esenciales y revisión del manuscrito Guadalupe Virginia Nevárez-Moorillón: revisión sistematica de la actividad biológica de los aceites esenciales, revisión de los estudios de simulación computacional y modelado molecular de los sesquiterpenos y dianas biológicas, y revisión del manuscrito Luvia E. Sánchez-Torres: revisión sistemática de la actividad de los componentes y escritura del manuscrito Sergio Andrade-Ochoa participó en todas las étapas del estudio. Essential oils and their components as an alternative in the control of mosquito vectors of diseaseMore than half of the human population is exposed to mosquito-borne infections. Climate change and the emergence of strains resistant to traditionally used insecticides have motivated the search of new agents for mosquito population control. Essential oils have been effective repellents and larvicidal agents. The aim of this work was to review research studies conducted in recent years on the larvicidal activity of essential oils and their components against Aedes, Anopheles and Culex mosquitoes, as well as the latest reports about their possible mechanism of action. Más de la mitad de la población humana está expuesta a contraer infecciones transmitidas por mosquitos. La falta de tratamientos y vacunas eficaces para muchas de estas enfermedades hace que su control dependa principalmente de la utilización de agentes insecticidas (1). Los individuos que habitan en las áreas tropicales están más expuestos a contraer enfermedades transmitidas por vectores y este riesgo ha aumentado en otras zonas debido a la globalización (2).Culex, Aedes y Anopheles son vectores de diversas enfermedades, como la filariasis, el dengue, la malaria, y otras. Culex quinquefasciatus está presente en vastas regiones tropicales del mundo, es la principal plaga doméstica en muchas áreas urbanas y está implicada en la transmisión de muchos agentes patógenos, entre ellos, el causante de la filariasis linfática. Esta enfermedad está ampliamente distribuida en las zonas tropicales, con alrededor de 120 millones de personas infectadas en todo el mundo (3).

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Mode of action of the plant-derived silphinenes on insect and mammalian GABAA receptor/chloride channel complex

Cited by 47 publications

References 19 publications

Triterpene-based plant defenses

Triterpene-based plant defenses

Essential oils for the development of eco-friendly mosquito larvicides: A review

Essential oils and their components as an alternative in the control of mosquito vectors of disease

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