Mode of Action of Insulin, Carbutamide, and Tolbutamide.

Galansino, Giorgio; D’Amico, Giuseppe; Kanameishi, Doris; Foà, Piero P.

doi:10.3181/00379727-99-24379

Cited by 20 publications

(6 citation statements)

References 3 publications

(4 reference statements)

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“…There have been several reports which compared the effects of the routes of insulin delivery. Some [12,22] claimed that there was no change between portal and peripheral infusion while others [23][24][25][26][27] reported that peripheral insulin infusion was more effective, and vice versa [28,29]. These inconsistencies in the reported results may well be a consequence of the different experimental protocols, including different experimental stimulatory actions, baseline conditions, and methods of data assessment.…”

Section: Discussionmentioning

confidence: 99%

Blood glucose control and insulin clearance in unrestrained diabetic dogs portally infused with a portable insulin delivery system

et al. 1980

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Long term glucose control in pancreatectomised dogs has been obtained with portal insulin therapy. When compared to a previous similar study using peripheral infusions, 20% less exogenous insulin was required and peripheral fasting insulin levels were 30% lower. Animals (n = 5) were unrestrained, conscious and carried a programmable insulin pump for 163-224 days. In the post-absorptive state blood glucose was normal (87 _+ 5 mg/dl) as was plasma insulin (10 + 1 mU/1) with porcine insulin infused at a basal rate of 0.36 _+ 0.01 mU/kg/min. Following ingestion of a standard mixed meal the infusion rate was increased to 2.47 + 0.09 mU/kg/ rain for 71/2 h resulting in post-prandial normalisation of blood glucose. Peripheral plasma insulin levels were twice normal during the post-prandial infusion, but only half those previously reported with peripheral infusions. Insulin clearance rates were 37 ml/kg/min in the basal state and rose significantly post-prandially. In the absence of extra mealtime insulin the clearance rate was unaffected by the resulting post-prandial hyperglycaemia and similar to values observed with insulin infused peripherally at 0.45 + 0.03 mU/kg/min. No significant increase in the post-prandial rate of insulin clearance relative to the fasting rate was observed with peripherally administered insulin. It was thus concluded that portal insulin replacement in pancreatectomised dogs could normalise both blood glucose and insulin in the fasting state, but post-prandial peripheral insulin levels remained elevated.

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Section: Discussionmentioning

confidence: 99%

Blood glucose control and insulin clearance in unrestrained diabetic dogs portally infused with a portable insulin delivery system

et al. 1980

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“…Figure 2 shows the results of three studies in a diabetic patient given DL-lactate-2-C14 in the iv infusion of a lactate load. This method of administration was used in order to erase possible differences in lactate pool size between the contrasting states of no treatment and insulin administration (18). In all three studies, blood levels of lactate7 were between 16 and 20 mg per 100 ml during infusion, although the level remained relatively high for some time after infusion in the acutely diabetic condition.…”

Section: Methodsmentioning

confidence: 99%

Conversion of Dl-Lactate-2-C14 or -3-C14 or Pyruvate-2-C14 to Blood Glucose in Humans: Effects of Diabetes, Insulin, Tolbutamide, and Glucose Load*

Meutter¹

1963

J. Clin. Invest.

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“…Galansino e t al. (9) infused insulin in various doses into either the femoral or the portal vein of mongrel dogs and followed the changes in glucose concentration in the peripheral venous blood. No differences were noted between the two routes when insulin was infused in a dose of I U/kg/S min, whereas significant differences were obtained when the dose was reduced to 0.1 U/kg/S min.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effect of Intraportal and Intravenous Infusion of Insulin on Blood Glucose and Free Fatty Acids in Peripheral Venous Blood of Man

Erwald

Hed

Nygren

et al. 1974

Journal of Internal Medicine

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The peripheral venous hypoglycemic and awake patients who had previously been subjected hypolipacidemic responses to intraportal infusions of in-to portal vein catheterization. The intention was to sulin have been compared with the responses obtained study the influence of the insulin infusion site on after i.v. infusions of identical amounts of insulin in 14 unanesthetized patients. The i.v. route of insulin the hypoglycemic and the hyPO1ipacidemic readministration resulted in a more pronounced hypo-sponses in peripheral venous blood. lipacidemic response than the intraportal administration route. The hypoglycemic responses, however, as reflected in the peripheral venous blood, did not differ significantly after either route of insulin administration.

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Mode of Action of Insulin, Carbutamide, and Tolbutamide.

Cited by 20 publications

References 3 publications

Blood glucose control and insulin clearance in unrestrained diabetic dogs portally infused with a portable insulin delivery system

Blood glucose control and insulin clearance in unrestrained diabetic dogs portally infused with a portable insulin delivery system

Conversion of Dl-Lactate-2-C14 or -3-C14 or Pyruvate-2-C14 to Blood Glucose in Humans: Effects of Diabetes, Insulin, Tolbutamide, and Glucose Load*

Comparison of the Effect of Intraportal and Intravenous Infusion of Insulin on Blood Glucose and Free Fatty Acids in Peripheral Venous Blood of Man

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