Mode of Action of Biogenic Silver, Zinc, Copper, Titanium and Cobalt Nanoparticles Against Antibiotics Resistant Pathogens

Summer, Muhammad; Ali, Shaukat; Tahir, Hafiz Muhammad; Abaidullah, Rimsha; Fiaz, Umaima; Mumtaz, Shumaila; Fiaz, Hashim; Hassan, Ali; Mughal, Tafail Akbar; Farooq, Muhammad Adeel

doi:10.1007/s10904-023-02935-y

Cited by 3 publications

(1 citation statement)

References 392 publications

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“…Nanoparticles require specialized coatings for treatment of specific organs and infections. Metal nanoparticles are likely toxic to bacteria through their generation of reactive oxygen species; , while this mechanism is less amenable to evasion by bacteria, metal nanoparticles also can potentially be toxic to normal cells and to cells upon emission into the environment. Antibacterial films (if used internally), implants, and composites are mechanically stable, but the release of coatings or fragments from films or implants may lead to undesired toxicity.…”

Section: Antibioticsmentioning

confidence: 99%

Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies

Ralhan,

Iyer,

Diaz

et al. 2024

ACS Infect. Dis.

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The development of effective antibacterial solutions has become paramount in maintaining global health in this era of increasing bacterial threats and rampant antibiotic resistance. Traditional antibiotics have played a significant role in combating bacterial infections throughout history. However, the emergence of novel resistant strains necessitates constant innovation in antibacterial research. We have analyzed the data on antibacterials from the CAS Content Collection, the largest human-curated collection of published scientific knowledge, which has proven valuable for quantitative analysis of global scientific knowledge. Our analysis focuses on mining the CAS Content Collection data for recent publications (since 2012). This article aims to explore the intricate landscape of antibacterial research while reviewing the advancement from traditional antibiotics to novel and emerging antibacterial strategies. By delving into the resistance mechanisms, this paper highlights the need to find alternate strategies to address the growing concern.

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Section: Antibioticsmentioning

confidence: 99%

Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies

Ralhan,

Iyer,

Diaz

et al. 2024

ACS Infect. Dis.

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Radical scavenging potential of spectrophotometric, spectroscopic, microscopic, and EDX observed zinc oxide nanoparticles from leaves, buds, and flowers extract of Bauhinia Variegata Linn: A thorough comparative insight

Abbas,

Irshad,

Ali

et al. 2024

Microscopy Res & Technique

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The present study incorporated an environment‐friendly and cost‐efficient green synthesis method for fabricating zinc oxide nanoparticles (ZnO‐NPs) using various parts (leaves, buds, and flowers) of Bauhinia Variegate Linn. UV‐Spectrophotometric analysis was used to confirm the synthesis of ZnO‐NPs, which showed an absorption band within 360–380 nm range. Further techniques like FT‐IR spectroscopy and (SEM) scanning electron microscopy equipped with a novel EDX were also included to confirm the synthesis, size, and shape of ZnO‐NPs. Results obtained by FT‐IR showed that the phytochemicals present in the ethanolic extract successfully acted as a capping agent. SEM micrographs confirmed irregularly shaped nanoparticles with an average size of 70–80 nm. The presence of Zinc and Oxygen peaks in EDX also confirmed the successful synthesis of ZnO nanoparticles. The radical scavenging (antioxidant) potential of prepared nanoparticles was also evaluated by DPPH radical assay. The ZnO‐NPs obtained from the ethanolic extract of buds showed the highest %RSA (86%) as compared to the flowers (79%) and leaves (76%). The current study findings showed the versatile morphology of all parts of the plant with significant antioxidant potential, establishing the use of Bauhinia Variegate in biological systems for various biomedical applications.Research Highlights A thorough comparative analysis of the radical scavenging power of major parts of the Bauhinia Variegate, which is 1st of its kind. Extensive characterization using UV–Vis spectrophotometry, FT‐IR, SEM, and EDX to observe the conformational and morphological changes. Analysis of the reduction potential of leaves, buds, and flowers of a single plant for future directions in green synthesis.

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Recent advancements of nanotechnology in fish aquaculture: an updated mechanistic insight from disease management, growth to toxicity

Sharjeel,

Ali,

Summer

et al. 2024

Aquacult Int

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Mode of Action of Biogenic Silver, Zinc, Copper, Titanium and Cobalt Nanoparticles Against Antibiotics Resistant Pathogens

Cited by 3 publications

References 392 publications

Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies

Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies

Radical scavenging potential of spectrophotometric, spectroscopic, microscopic, and EDX observed zinc oxide nanoparticles from leaves, buds, and flowers extract of Bauhinia Variegata Linn: A thorough comparative insight

Recent advancements of nanotechnology in fish aquaculture: an updated mechanistic insight from disease management, growth to toxicity

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