Mode of Action and Resistance Mechanisms of Antimicrobial Macrolides

Nakajima, Yoshinori

doi:10.1016/b978-012526451-8/50011-4

Cited by 10 publications

(14 citation statements)

References 167 publications

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“…Although AMPs are highly diverse, and span the range from prokaryotes to lower and higher eukaryotes, many AMPs have conserved structural features, with common amphiphilic and alpha helical domains (Jenssen et al, 2006;Fjell et al, 2012;Uggerhøj et al, 2015;Haney et al, 2017). A common mechanism by which AMPs exert direct antimicrobial activity involves the accumulation of the peptide on the bacterial cell surface, with subsequent membrane disruption, leading to cell death (Nakajima, 2003;Brogden, 2005;Lv et al, 2014;Ong et al, 2014;Mahlapuu et al, 2016). Strategies to improve the activity of natural AMPs have focused on biophysical approaches to increase both the targeting affinity for anionic bacterial membranes and to improve their ability to penetrate lipid membrane domains, as well as altering properties including heat stability, solubility, and protease resistance for more effective therapeutic use (Fjell et al, 2012;Field et al, 2015a;Mikut et al, 2016;Torres et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity

et al. 2020

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“…Several studies showed that plant secondary metabolites had antimicrobial activity. Ferulic acid, quercetin, macrolide, and other compounds in triterpene samples have been exhibited dramatic antibacterial and anti-mycoplasma activities (Dinesh Kumar et al, 2016;Kalinowska et al, 2014;Nakajima, 2003). Other studies have shown that flavonoids in the plant extracts have certain antibacterial activities (Al-Huqail et al, 2019;Suhaili Shamsi et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

The analysis of flavonoids and triterpenes extracted from Urtica by LC‐MS and the antimicrobial activity of the extracts

Quan¹,

Sun²,

Liu³

et al. 2021

J. Food Process. Preserv.

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Functional foods and drug industries have been rapidly developed.Natural products can be used as antioxidants, antimicrobial agents, and raw materials in pharmaceutical production (Dai & Mumper, 2010).Bioactive substances extracted from plants are widely used in medicine and food. Several methods have been developed for extracting, isolating, and purifying flavonoids and triterpenoids. However, more simple, efficient, and less expensive methods to produce large-scale high-quality products are urgently needed.Urtica fissa E. Pritz., Urticaceae is a perennial herb with 100-180cm of the whole plant height, transverse rhizome, tetra-prismatic, densely ciliate and puberulent, sparsely branched. It is a common shadeloving plant, featured by vigorous life, rapid growth, lax soil requirements, favoring of warm and wet characteristics. It usually grows in the hillside, roadside, or house half shade wet place (Weigend, 2006).Urtica is a relatively common wild plant. Its generic name comes from the Latin word urere, meaning "to rub or burn." Stems and leaves of urtica are covered with fine cilia, containing ingredients such as formic acid and histamine. There is an intense burning sensation when stunning (Bourgeois et al., 2016). Urtica is also widely distributed geographically. It grows in Eurasia, North America, and North Africa,

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“…In the carpet model, AMPs act without forming specific pores in the membrane [ 32 , 33 ]. Rather, the AMPs accumulate parallel to the lipid bilayer and reach the surface concentration needed to envelop the surface of the membrane, thereby forming a ‘carpet’.…”

Section: Mode Of Action Of Ampsmentioning

confidence: 99%

Antimicrobial Peptide Mechanisms Studied by Whole-Cell Deuterium NMR

Kumari

Booth

2022

IJMS

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Much of the work probing antimicrobial peptide (AMP) mechanisms has focussed on how these molecules permeabilize lipid bilayers. However, AMPs must also traverse a variety of non-lipid cell envelope components before they reach the lipid bilayer. Additionally, there is a growing list of AMPs with non-lipid targets inside the cell. It is thus useful to extend the biophysical methods that have been traditionally applied to study AMP mechanisms in liposomes to the full bacteria, where the lipids are present along with the full complexity of the rest of the bacterium. This review focusses on what can be learned about AMP mechanisms from solid-state NMR of AMP-treated intact bacteria. It also touches on flow cytometry as a complementary method for measuring permeabilization of bacterial lipid membranes in whole bacteria.

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Mode of Action and Resistance Mechanisms of Antimicrobial Macrolides

Cited by 10 publications

References 167 publications

Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity

Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity

The analysis of flavonoids and triterpenes extracted from Urtica by LC‐MS and the antimicrobial activity of the extracts

Antimicrobial Peptide Mechanisms Studied by Whole-Cell Deuterium NMR

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