Abstract:Ticagrelor is a perorally available P2Y12 receptor antagonist used for the prevention of cardiovascular events. In the present study, we analyzed the mode of action of ticagrelor at the recombinant human P2Y12 receptor and mutant constructs stably expressed in CHO Flp‐In cells. ADP and its analogue 2‐methylthio‐ADP (2‐MeSADP) decreased forskolin‐induced cAMP‐accumulation in a concentration dependent manner with 2‐MeSADP being more potent than ADP. Ticagrelor (3 to 10 nM) itself did not change basal and forskol… Show more
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