Modality composition and functional characteristics of dorsal column mechanoreceptive afferent fibers innervating the raccoon's forepaw

Lm, Pubols; Bh, Pubols

doi:10.1152/jn.1973.36.6.1023

Cited by 29 publications

(11 citation statements)

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“…Each stimulus produces the optimal response for one class of cutaneous mechanoreceptor, and all were applied during the study of individual thalamic neurons (see Techniques of Thalamic Electrophysiological Mapping in Humans, Monkeys, and Raccoons). Thalamic neuronal responses were found to be similar to those of one of the four classes of peripheral mechanoreceptor (Pubols and Pubols 1973). These results are consistent with studies of neuronal responses to cutaneous stimuli in old world monkeys (Mountcastle et al 1969;Sinclair et al 1991).…”

Section: Normal Somatic Sensory Thalamus: Responses To Optimal Tactilsupporting

confidence: 87%

“…The somatotopic map is consistent with the details of the mapping of VP in monkeys including the concave medial lamellae, the dorsal-to-ventral progression down the limbs, and the medialto-lateral progression of RFs with oral structures medial and legs lateral Pubols 1968). Histological evidence of this functional map can be shown by standard Nissl stains or by cytochrome oxidase staining of terminations of fibers from the dorsal column nuclei (Lin et al 1979;Jones 1991a, 1991b).…”

Section: Normal Somatic Sensory Thalamus: Summarysupporting

confidence: 75%

“…These cutaneous stimuli were identified as optimal stimuli for each class of primary afferent mechanoreceptor (Johnson et al 2000;Pubols and Pubols 1973). For studies of each neuron with precise stimuli, the hand is held in a malleable plastic cast that fixes the hand in position relative to the stimulator, which was positioned by a multijointed manipulandum.…”

Section: Techniques Of Thalamic Electrophysiological Mapping In Humanmentioning

confidence: 99%

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Neuronal responses to tactile stimuli and tactile sensations evoked by microstimulation in the human thalamic principal somatic sensory nucleus (ventral caudal)

Schmid

Chien

Greenspan

et al. 2016

Journal of Neurophysiology

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. Neuronal responses to tactile stimuli and tactile sensations evoked by microstimulation in the human thalamic principal somatic sensory nucleus (ventral caudal). J Neurophysiol 115: 2421-2433, 2016. First published February 10, 2016 doi:10.1152/jn.00611.2015.-The normal organization and plasticity of the cutaneous core of the thalamic principal somatosensory nucleus (ventral caudal, Vc) have been studied by single-neuron recordings and microstimulation in patients undergoing awake stereotactic operations for essential tremor (ET) without apparent somatic sensory abnormality and in patients with dystonia or chronic pain secondary to major nervous system injury. In patients with ET, most Vc neurons responded to one of the four stimuli, each of which optimally activates one mechanoreceptor type. Sensations evoked by microstimulation were similar to those evoked by the optimal stimulus only among rapidly adapting neurons. In patients with ET, Vc was highly segmented somatotopically, and vibration, movement, pressure, and sharp sensations were usually evoked by microstimulation at separate sites in Vc. In patients with conditions including spinal cord transection, amputation, or dystonia, RFs were mismatched with projected fields more commonly than in patients with ET. The representation of the border of the anesthetic area (e.g., stump) or of the dystonic limb was much larger than that of the same part of the body in patients with ET. This review describes the organization and reorganization of human Vc neuronal activity in nervous system injury and dystonia and then proposes basic mechanisms. amputation; dystonia; neurophysiology; spinal transection; single neuron recordings; ventral posterior thalamus

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Section: Normal Somatic Sensory Thalamus: Responses To Optimal Tactilsupporting

confidence: 87%

Section: Normal Somatic Sensory Thalamus: Summarysupporting

confidence: 75%

Section: Techniques Of Thalamic Electrophysiological Mapping In Humanmentioning

confidence: 99%

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Neuronal responses to tactile stimuli and tactile sensations evoked by microstimulation in the human thalamic principal somatic sensory nucleus (ventral caudal)

Schmid

Chien

Greenspan

et al. 2016

Journal of Neurophysiology

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“…Recordings from the star-nosed mole also suggested this separation into three classes. This division of afferents serving glabrous skin into three classes is well established for a considerable number of different animal model systems and humans (Lindblom, 1965;Jänig et al, 1968;Talbot et al, 1968;Iggo and Ogawa, 1977;Jänig, 1971;Pubols et al, 1971;Pubols and Pubols, Jr, 1973;Johnson, 1974;Dykes and Terzis, 1979; Johansson and Vallbo, 1979;Ferrington and Rowe, 1980;Vallbo and Johansson, 1984;Gregory et al, 1988;Leem et al, 1993;Iggo et al, 1996;Coleman et al, 2001;Mahns et al, 2003). Previous histological studies in the mole routinely reveal a preponderance of three main types of receptor end-organ in the glabrous rhinarium (Fig.·1).…”

Section: Receptor Classesmentioning

confidence: 69%

Response properties of primary afferents supplying Eimer's organ

Marasco

Catania

2007

Journal of Experimental Biology

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SUMMARY The mole's nose is covered with mechanosensory structures called Eimer's organs. Each organ contains Merkel cell-neurite complexes, Paciniform corpuscles and intraepidermal free nerve endings. The function of Eimer's organ has been the subject of speculation since the 1800s, but responses from the afferents have never been investigated. Our goal was to explore the function of Eimer's organ by recording primary afferent responses to a range of mechanosensory stimuli. Unit activity from the trigeminal ganglion was recorded from coast (Scapanus orarius) and star-nosed (Condylura cristata) moles, while stimulating the nose with a Chubbuck mechanosensory stimulator, a piezo-electric sweeping stimulator, and hand-held probes. Stimuli included static indentations, sinusoidal displacements,different indentation velocities, displacement amplitudes, and directional stimuli across the skin. Receptive fields were small, sometimes restricted to single Eimer's organs. Responses were consistent with a slowly adapting Merkel cell-neurite complex-like receptor class and a dynamically sensitive Pacinian-like rapidly adapting class. A second rapidly adapting class was hypothesized to represent activity of prominent free nerve endings within a central cell column. Some receptors were most sensitive to stimuli applied in particular directions across the skin. Most receptors relayed mechanosensory input with high temporal fidelity. In addition some receptors were tuned to respond best when stimulated at a velocity matching the velocity of the nose during foraging. These results support the hypothesis that Eimer's organ functions to detect small surface features and textures by encoding and integrating deflection information for multiple Eimer's organs during brief touches.

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“…In the ventral posterior thalamus of anesthetized marmosets and raccoons, neuronal response patterns have been compared with those of the mechanoreceptor classes (Hirai and Jones 1989;Warren et al 1986;Zhang et al 2001b), and each was found to be similar to that of the peripheral mechanoreceptors (Pubols and Pubols 1973). Studies of neuronal responses to cutaneous stimuli have also been reported in old world monkeys (Mountcastle et al 1969;Sinclair et al 1991).…”

Section: Introductionmentioning

confidence: 98%

The Human Thalamic Somatic Sensory Nucleus [Ventral Caudal (Vc)] Shows Neuronal Mechanoreceptor-Like Responses to Optimal Stimuli for Peripheral Mechanoreceptors

Weiss

Ohara

Johnson

et al. 2009

Journal of Neurophysiology

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Weiss N, Ohara S, Johnson KO, Lenz FA. The human thalamic somatic sensory nucleus [ventral caudal (Vc)] shows neuronal mechanoreceptor-like responses to optimal stimuli for peripheral mechanoreceptors. J Neurophysiol 101: 1033-1042, 2009. First published November 12, 2008 doi:10.1152/jn.90990.2008. Although the response of human cutaneous mechanoreceptors to controlled stimuli is well studied, it is not clear how these peripheral signals may be reflected in neuronal activity of the human CNS. We now test the hypothesis that individual neurons in the human thalamic principal somatic sensory nucleus [ventral caudal (Vc)] respond selectively to the optimal stimulus for one of the four mechanoreceptors. The optimal stimuli for particular mechanoreceptors were defined as follows: Pacinian corpuscles (PC), vibration at 128 Hz; rapidly adapting (RA), vibration at 32 or 64 Hz; slowly adapting type 1 (SA1), edge; slowly adapting type 2 (SA2), skin stretch. Nineteen neurons had a significant response to at least one optimal stimulus, and 17 had a significantly greater response to one stimulus than to the other three, including 7 PC-related, 7 RA-like, 3 SA1-like, and 2 SA2-like neurons. One of each of the SA1-and SA2-like thalamic neurons responded to vibration with firing rates that were lower than those to edge or stretch but not significantly. Except in the case of PC-related neurons, the receptive field (RF) sizes were larger for these thalamic neurons than for the corresponding mechanoreceptor. Von Frey thresholds were higher than those for the corresponding human RA and SA1 mechanoreceptors. These results suggest that there is a convergence of pathways transmitting input from multiple mechanoreceptors of one type on single thalamic neurons via the dorsal columns. They are also consistent with the presence of primate thalamic elements of modality and somatotopic isorepresentation.

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Modality composition and functional characteristics of dorsal column mechanoreceptive afferent fibers innervating the raccoon's forepaw

Cited by 29 publications

References 0 publications

Neuronal responses to tactile stimuli and tactile sensations evoked by microstimulation in the human thalamic principal somatic sensory nucleus (ventral caudal)

Neuronal responses to tactile stimuli and tactile sensations evoked by microstimulation in the human thalamic principal somatic sensory nucleus (ventral caudal)

Response properties of primary afferents supplying Eimer's organ

The Human Thalamic Somatic Sensory Nucleus [Ventral Caudal (Vc)] Shows Neuronal Mechanoreceptor-Like Responses to Optimal Stimuli for Peripheral Mechanoreceptors

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