Modality-Based Organization of Ascending Somatosensory Axons in the Direct Dorsal Column Pathway

Niu, Jingwen; Ding, Long; Li, Jian J.; Kim, Hyukmin; Liu, Jiakun; Li, Haipeng; Moberly, Andrew H.; Badea, Tudor C.; Duncan, Ian D.; Son, Young–Jin; Scherer, Steven S.; Luo, Wenqin

doi:10.1523/jneurosci.3429-13.2013

Cited by 110 publications

(133 citation statements)

References 49 publications

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“…Immunohistochemistry, in situ hybridization, and image analysis are similar to those previously described (Fleming et al, 2015;Niu et al, 2013;Niu et al, 2014). The detailed experimental procedures are described in the Supplemental Experimental Procedures.…”

Section: Immunohistochemistry In Situ Hybridization and Image Analysismentioning

confidence: 86%

“…Since many afferent branches were disconnected during slice preparation, and since Aβ fibers from adjacent dorsal roots also innervate the examined spinal level (Brown, 1981;Niu et al, 2013) (Figure 3N), we speculated that 35.2% is an under estimation of Aβ inputs. To test this idea, we generated Vglut1 Cre ; Rosa ChR2(f)/+ ; Ret CFP/+ mice, in which a blue lightactivated cation channel, channelrhodopsin (ChR2) (Boyden et al, 2005), is specifically expressed in all VGLUT1+ neurons, including Aβ fibers ( Figures S4A-F Figures 3J-M).…”

Section: Ret+ Ddh Neurons Receive Excitatory Inputs From Aβ Mechanosementioning

confidence: 99%

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Identification of Early RET+ Deep Dorsal Spinal Cord Interneurons in Gating Pain

Cui¹,

Miao²,

Liang³

et al. 2016

Neuron

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The gate control theory (GCT) of pain proposes that pain-and touch-sensing neurons antagonize each other through spinal cord dorsal horn (DH) gating neurons. However, the exact neural circuits underlying the GCT remain largely elusive. Here, we identified a new population of deep layer DH (dDH) inhibitory interneurons that express the receptor tyrosine kinase Ret neonatally. These early RET+ dDH neurons receive excitatory as well as polysynaptic inhibitory inputs from touch-and/or pain-sensing afferents. In addition, they negatively regulate DH pain and touch pathways through both pre-and postsynaptic inhibition. Finally, specific ablation of early RET+ dDH neurons increases basal and chronic pain, whereas their acute activation reduces basal pain perception and relieves inflammatory and neuropathic pain. Taken together, our findings uncover a novel spinal circuit that mediates crosstalk between touch and pain pathways and suggest that some early RET + dDH neurons could function as pain "gating" neurons.

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Section: Immunohistochemistry In Situ Hybridization and Image Analysismentioning

confidence: 86%

Section: Ret+ Ddh Neurons Receive Excitatory Inputs From Aβ Mechanosementioning

confidence: 99%

Identification of Early RET+ Deep Dorsal Spinal Cord Interneurons in Gating Pain

Cui¹,

Miao²,

Liang³

et al. 2016

Neuron

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“…Using semi-thin sections stained with toluidine blue to visualize axon cross-section profiles within the dorsal column, we found that the volume of the gracile fasciculus, which mainly contains the ascending axons of RA mechanoreceptors (Niu et al, 2013), was greatly reduced in mutant mice compared to controls (Figures 6N-O). Thus, no recovery in axon volume occurs even at later stages.…”

Section: Resultsmentioning

confidence: 99%

“…We previously characterized the functional organization of the DDC pathway (Niu et al, 2013), which contains the ascending axons of Aβ mechanoreceptors and proprioceptors. We showed that ascending axons of Aβ rapidly-adapting (RA) mechanoreceptors and proprioceptors are largely segregated.…”

Section: Introductionmentioning

confidence: 99%

Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons

et al. 2018

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SUMMARY Spinal cord longitudinal axons comprise some of the longest axons in our body. However, mechanisms that drive this extra long-distance axonal growth are largely unclear. We found that ascending axons of rapidly adapting (RA) mechanoreceptors closely abut a previously undescribed population of roof plate-derived radial glial-like cells (RGLCs) in the spinal cord dorsal column, which form a network of processes enriched with growth-promoting factors. In dreher mutant mice that lack RGLCs, the lengths of ascending RA mechanoreceptor axon branches are specifically reduced, whereas their descending and collateral branches, and other dorsal column and sensory pathways, are largely unaffected. Since the number and intrinsic growth ability of RA mechanoreceptors are normal in dreher mice, our data suggest that RGLCs provide a critical non-cell autonomous growth support for the ascending axons of RA mechanoreceptors. Together, our work identifies a novel developmental mechanism specifically required for long-range spinal cord longitudinal axons.

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“…La postura de activación es fuente de aferencias sobre el SNC por medio de la información propioceptiva que proporcionan músculos, articulaciones y ligamentos (11,21). Esta postura de activación induce al GCP, activando la respuesta neuronal que producen periódicamente los patrones rítmicos de locomoción (22,23).…”

Section: Resultsunclassified

Revisión del abordaje terapéutico mediante el principio vojta sobre las alteraciones de la marcha en pacientes neurológicos

Esteban¹,

Sanz²,

Jorge³

et al. 2017

Eur J Pod

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Review of the therapeutic approach by the vojta principle in neurological patients with gait disordersRevisión del abordaje terapéutico mediante el principio vojta sobre las alteraciones de la marcha en pacientes neurológicos Results: After using the criteria of inclusion and exclusion were collected 3 thesis, 35 articles and 7 relevant books of different databases. During the reflex locomotion therapy (RLT), the central nervous system (CNS) seems to be activated probably due to the influence of the posture and stimulus points. All the afferent propioceptive information could cause an innate response in locomotion coordination complex which humans use during gait. Conclusions:Patients with neurological disorders could be improved by the of Vojta therapy in different gait parameters. Vojta therapy (VT) could obtain the activation of cortical and subcortical levels that intervenes during locomotion. More randomized clinical trial are necessary to increase the evidence about Vojta therapy in gait pattern of neurological diseases.Key Words: Physical therapy modalities, gait disorders, neurologic, locomotion, gait rehabilitation, cerebral stroke, cerebral palsy, multiple sclerosis. ResumenObjetivos: Revisar en la bibliografía el abordaje terapéutico del principio Vojta y la importancia de la activación de los programas motores innatos para la mejora funcional de la marcha. Métodos: Se recopilan los datos tras una búsqueda en las bases PUBMED, MEDLINE, otros recursos como Google Scholar y la biblioteca de la Universidad Europea de Madrid, siguiendo los criterios Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) y checklist. Se recogen los datos durante los meses de enero y febrero del 2017. Resultados: Tras aplicar los criterios de inclusión y exclusión resultan relevantes 3 tesis doctorales, 35 artículos y 7 libros de las distintas bases de datos. Durante la terapia de locomoción refleja (TLR) parece producirse una importante activación del sistema nervioso central (SNC) posiblemente debido a la influencia de la postura y la activación de los puntos de estímulo. Toda la información aferente propioceptiva podría provocar la respuesta innata de los complejos de coordinación locomotores que utiliza el ser humano durante la marcha. Conclusiones: Los pacientes con alteraciones neurológicas podrían beneficiarse de la terapia Vojta (TV) al obtener mejorías en diferentes parámetros de la marcha. La TV podría conseguir activar zonas a nivel cortical y subcortical que intervienen durante el movimiento locomotor. Son necesarios ensayos clínicos aleatorizados que aumenten la evidencia científica de la terapia Vojta en los patrones de marcha de patologías neurológicas.Palabras Clave: Fisioterapia, locomoción, rehabilitación de la marcha, alteraciones de la marcha, neurológicas, daño cerebral, parálisis cerebral, esclerosis múltiple.

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Modality-Based Organization of Ascending Somatosensory Axons in the Direct Dorsal Column Pathway

Cited by 110 publications

References 49 publications

Identification of Early RET+ Deep Dorsal Spinal Cord Interneurons in Gating Pain

Identification of Early RET+ Deep Dorsal Spinal Cord Interneurons in Gating Pain

Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons

Revisión del abordaje terapéutico mediante el principio vojta sobre las alteraciones de la marcha en pacientes neurológicos

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